Angioplastia primária na mulher: realidade nacional | Revista Portuguesa de Cardiologia

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De facto, na Europa, cerca de 23% das mortes no sexo feminino são por doença coronária<a class="elsevierStyleCrossRef" href="#bib0005">1</a>. A proporção de mulheres com doença coronária diagnosticada tem vindo a crescer nos últimos anos, no entanto, e quando comparada com os homens, esta continua a ser uma patologia subdiagnosticada e subtratada nas mulheres, com menor recurso a estratégias de revascularização e à terapêutica médica otimizada<a class="elsevierStyleCrossRef" href="#bib0010">2</a>. Por outro lado, continua a existir a crença de que a mulher tem pior prognóstico do que o homem após angioplastia primária (ICP‐P)<a class="elsevierStyleCrossRefs" href="#bib0015">3,4</a>. A maior mortalidade na mulher pode ser explicada por esta constituir um grupo de maior risco cardiovascular, pela doença ser subdiagnosticada e subtratada ou, ainda, por uma diferente anatomia e resposta biológica ao enfarte, inerente ao sexo<a class="elsevierStyleCrossRef" href="#bib0015">3</a>. Registos prévios apresentam resultados contraditórios em relação ao sexo como fator de risco independente para mortalidade no contexto de enfarte agudo do miocárdio com supradesnivelamento de ST (EAMST)<a class="elsevierStyleCrossRefs" href="#bib0015">3–7</a>.Com base no Registo Nacional de Cardiologia de Intervenção (RNCI), foi nosso objetivo analisar o panorama nacional do tratamento do EAMST por ICP‐P nas mulheres e avaliar de que forma o género influencia o prognóstico hospitalar nestes doentes.MétodosPopulação e métodosO RNCI é um registo observacional prospetivo de doentes submetidos a intervenção percutânea em diferentes unidades de cardiologia de intervenção do país. Entre 4 de janeiro de 2002 e 24 de julho de 2012 foram incluídos 60 158 doentes, em 22 centros nacionais. Analisamos retrospetivamente 7.544 doentes consecutivos submetidos a ICP‐P no contexto de EAMST com menos de 12 horas de evolução. A definição de EAMST foi dada através da presença de sintomas compatíveis com isquemia do miocárdio com uma duração superior a 30 minutos e supradesnivelamento de ST persistente (superior a 1mm em duas derivações contíguas) ou bloqueio completo de ramo esquerdo de novo ou desconhecido. Foram excluídos os doentes submetidos a trombólise no caso índex.Não houve critérios de exclusão relativamente à complexidade da forma de apresentação do EAMST ou à natureza das lesões.Todos os doentes deram o consentimento informado aquando da sua inclusão na base de dados prospetiva.Compararam‐se os homens e as mulheres em relação às características demográficas, aos fatores de risco, à história clínica pregressa cardiovascular, à gravidade da doença, à localização do EAM e às características do procedimento.O seguimento clínico hospitalar foi obtido do RNCI.Análise estatísticaNesta análise, os grupos de homens e de mulheres foram caracterizados segundo variáveis contínuas e categóricas. As variáveis categóricas foram caracterizadas recorrendo a frequências absolutas e frequências relativas. A caracterização da tendência central e a da dispersão dos valores das variáveis contínuas foi estimada recorrendo à média amostral e ao desvio padrão, ou à mediana e ao intervalo interquartil, conforme se verificou ou não simetria na distribuição dos seus valores.A comparação das variáveis categóricas foi realizada utilizando o teste qui‐quadrado ou o teste exato de Fisher, conforme o mais apropriado. Enquanto a comparação das variáveis contínuas foi realizada usando o teste t de Student ou o teste Mann‐Whitney quando os pressupostos para a utilização do primeiro não eram satisfeitos. A normalidade da distribuição dos valores das variáveis contínuas foi testada usando o teste de Kolmogorov‐Smirnov e a igualdade das respetivas variâncias pelo teste de Levene.O impacto que cada uma das variáveis consideradas (incluindo o sexo) tem na mortalidade foi avaliado numa análise univariável em que se estimou o odds ratio (OR) e respetivo intervalo de confiança a 95% (IC). Num primeiro modelo de regressão considerou‐se unicamente o sexo como variável independente. Posteriormente o impacto do sexo na mortalidade intra‐hospitalar foi ajustado à presença de outras variáveis construindo vários modelos de regressão logística. No segundo modelo ajustámos o impacto do sexo à presença de idade >65 anos. No terceiro modelo ajustámos o impacto do sexo à idade, aos fatores de risco (diabetes mellitus, hipertensão arterial, dislipidemia e tabagismo) e à história clínica pregressa cardiovascular (história prévia de EAM, revascularização percutânea ou cirúrgica, insuficiência cardíaca congestiva, acidente vascular cerebral, doença arterial periférica e insuficiência renal crónica). No quarto modelo consideraram‐se todas as variáveis do segundo juntamente com as variáveis clínicas de gravidade à admissão (presença de choque cardiogénico e EAM de localização anterior). O quinto modelo foi ajustado para todas as variáveis mencionadas previamente e ainda para as características do procedimento (tipo de acesso, tipo de stent e trombectomia).De forma a minimizar a influência de bias de seleção num estudo não aleatorizado, uma segunda análise foi realizada usando a regressão logística na determinação de um score de propensão, em que se considerou o sexo como variável dependente. O score de propensão foi usado no emparelhamento de mulheres e homens numa razão 1:1. As variáveis utilizadas no cálculo do score de propensão foram: idade, fatores de risco e antecedentes cardiovasculares. Após o emparelhamento dos indivíduos dos dois sexos, o risco estimado de ocorrência de morte intra‐hospitalar para as mulheres, quando comparadas com os homens, foi ajustado novamente por intermédio de um modelo de regressão logística em que foram incluídas as mesmas variáveis consideradas no quarto modelo descrito acima.Na construção de todos os modelos de regressão logística referidos na determinação dos preditores de morte intra‐hospitalar, o sexo foi forçado a entrar no modelo ao ser incluído no primeiro bloco de variáveis, enquanto os outros preditores foram selecionados a partir de um segundo bloco de variáveis, usando o método forward stepwise. A boa calibração dos modelos de regressão logística foi testada pelo teste de Hosmer e Lemeshow. Enquanto as suas capacidades discriminatórias foram avaliadas a partir das estimativas das respetivas áreas sob a curva ROC.Foi considerado nesta análise o nível de significância de 5%.A análise estatística foi realizada com o software estatístico SPSS, versão 19.0.0.2.ResultadosCaracterísticas basaisForam incluídos 7544 doentes consecutivos do RNCI submetidos a angioplastia primária no contexto de EAMST. Os doentes foram divididos em dois grupos de acordo com o sexo: 1856 doentes (25%) mulheres e 5688 doentes (75%) homens. As características demográficas basais e a clínica de apresentação hospitalar encontram‐se descritas na <a class="elsevierStyleCrossRef" href="#tbl0005">Tabela 1</a>.<elsevierMultimedia ident="tbl0005"></elsevierMultimedia>As mulheres foram mais idosas (68±14 versus 61±13, p<0,001) e apresentaram maior prevalência de diabetes (30 versus 21%, p<0,001), hipertensão (69 versus 55%, p<0,001) e insuficiência renal crónica (4 versus 2%, p=0,002). Por outro lado, eram menos fumadoras (22 versus 57%, p<0,001) e com menor frequência apresentaram história de doença coronária prévia como EAM (11 versus 15%, p<0,001), revascularização percutânea (11 versus 16%, p<0,001) ou cirúrgica (1 versus 2%, p=0,008).O número de doentes submetidos a ICP‐P que recorreram diretamente a um centro com cardiologia de intervenção foi superior no sexo feminino (91 versus 89%, p=0,014), no entanto, esse fator não influenciou o tempo porta‐balão que foi semelhante em ambos os sexos (<a class="elsevierStyleCrossRef" href="#tbl0010">Tabela 2</a>). Apesar disso, as mulheres foram revascularizadas mais tardiamente (4,6 versus 3,9 horas, p<0,001) porque recorreram mais tarde ao hospital (4,3 versus 3,7 horas, p<0,001). A percentagem de homens revascularizados nas primeiras seis horas do início dos sintomas foi superior à das mulheres (71 versus 63%, respetivamente, p<0,001).<elsevierMultimedia ident="tbl0010"></elsevierMultimedia>A evolução em choque cardiogénico foi mais frequente nas mulheres (7,1 versus 5,7%, p=0,032). Não houve diferenças no vaso culpável pelo EAM ou na extensão da doença coronária, com uma percentagem de doença multivaso semelhante em ambos os sexos.Características do procedimentoAs características do procedimento estão descritas na <a class="elsevierStyleCrossRef" href="#tbl0010">Tabela 2</a>. O acesso vascular usado com maior frequência em ambos os grupos foi o femoral. O acesso radial foi usado com menor frequência na mulher (14 versus 17%, p=0,001). Não houve diferenças no tipo de stent usado, mas procedeu‐se a mais trombectomia (23 versus 26%, p=0,003) e administração de inibidores da glicoproteína IIb/IIIa (27 versus 35%, p<0,001) nos homens. A obtenção de fluxo TIMI 3 no final do procedimento foi tendencialmente mais frequente no sexo masculino, traduzindo um melhor resultado angiográfico.Preditores da mortalidade hospitalarA mortalidade hospitalar foi superior nas mulheres (4,3 versus 2,5%, p<0,001). Estimou‐se que o risco de ocorrência de morte no sexo feminino seja 1,7 vezes superior ao risco no sexo masculino (IC 95%: 1,30‐2,27; p<0,001) (<a class="elsevierStyleCrossRef" href="#tbl0015">Tabela 3</a>).<elsevierMultimedia ident="tbl0015"></elsevierMultimedia>Após ajuste para a idade >65 anos, verifica‐se que este fator contribuiu largamente para explicar o excesso de risco das mulheres comparativamente aos homens (<a class="elsevierStyleCrossRef" href="#tbl0020">Tabela 4</a>). A partir da análise multivariável (<a class="elsevierStyleCrossRef" href="#fig0005">Figura 1</a>), os preditores independentes para a ocorrência de morte intra‐hospitalar foram a idade >65 anos, a doença arterial periférica, antecedentes de insuficiência cardíaca congestiva, evolução em choque cardiogénico e enfarte anterior. A presença de dislipidemia, o uso de stents revestidos por fármaco e o acesso radial foram variáveis protetoras. A área sob a curva ROC no modelo final foi de 0,88, o que traduz a excelente capacidade de discriminação do modelo obtido.<elsevierMultimedia ident="tbl0020"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia>A partir de um modelo de regressão logística, que considerou o sexo como variável dependente, determinou‐se um propensity score que posteriormente foi usado no emparelhamento de 1338 mulheres e 1338 homens, numa razão 1:1. Após ajuste usando este modelo estatístico, a mortalidade intra‐hospitalar entre mulheres e homens foi semelhante na ordem dos 3,9% (OR=1,00; IC 95%: 0,68‐1,48; p=1,00).Evolução da mortalidade hospitalar ao longo do período do estudoA prevalência da ICP‐P nas mulheres no RNCI tem vindo a crescer de forma linear ao longo dos anos (11% de 2002‐2005 versus 15% de 2006 a 2008 versus 19% de 2009 a 2012; p<0,001 para a tendência), semelhante ao observado nos homens (<a class="elsevierStyleCrossRef" href="#fig0010">Figura 2</a>). Ao longo dos anos incluídos no estudo a mortalidade hospitalar das mulheres foi sempre superior comparativamente com os homens, com diferenças que se acentuaram nos últimos anos (<a class="elsevierStyleCrossRef" href="#tbl0025">Tabela 5</a>).<elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0025"></elsevierMultimedia>Embora a taxa de mortalidade hospitalar tenha diminuído em termos absolutos em ambos os sexos, entre 2002‐2012, essa redução só foi significativa nos homens (<a class="elsevierStyleCrossRef" href="#fig0015">Figura 3</a>).<elsevierMultimedia ident="fig0015"></elsevierMultimedia>DiscussãoCaracterísticas clínicas e angiográficasÀ semelhança de muitos outros estudos de revascularização coronária, em ambos os contextos de cirurgia de revascularização coronária e de intervenção percutânea, a apresentação clínica da doença coronária varia entre os sexos<a class="elsevierStyleCrossRefs" href="#bib0015">3–6,8,9</a>. A mulher tem uma apresentação da síndrome coronária aguda numa idade mais avançada, em média uma década mais tarde, e mais frequentemente têm queixas atípicas em detrimento da angina clássica. As mulheres têm um pior perfil cardiovascular com maior prevalência de diabetes mellitus e hipertensão arterial. A acumulação de fatores de risco cardiovasculares é comum na mulher em idade pós‐menopausa<a class="elsevierStyleCrossRef" href="#bib0005">1</a>.Apesar do elevado perfil de risco da mulher submetida a angioplastia primária, a extensão da doença coronária é semelhante à do homem, com uma prevalência semelhante de doença multivaso<a class="elsevierStyleCrossRef" href="#bib0045">9</a>.A incidência de insuficiência cardíaca congestiva e de choque cardiogénico na admissão hospitalar é significativamente superior na mulher, apesar de terem menos história prévia de enfarte do miocárdio e apresentarem uma função ventricular esquerda semelhante. Esta observação é similar a muitos outros estudos<a class="elsevierStyleCrossRefs" href="#bib0015">3,4,9</a>. A maior prevalência de disfunção diastólica devido à idade avançada e à cardiopatia hipertensiva, tem sido a explicação mais frequentemente proposta<a class="elsevierStyleCrossRef" href="#bib0050">10</a>. Um miocárdio hipertrofiado pode ser menos tolerante a períodos isquémicos transitórios. A diminuição da compliance diastólica que ocorre após oclusão abrupta de vaso pode ser menos bem tolerada em doentes com hipertrofia ventricular esquerda<a class="elsevierStyleCrossRef" href="#bib0050">10</a>. Por outro lado, a maior incidência de instabilidade hemodinâmica à admissão pode ser explicada pelo facto de as mulheres chegarem ao laboratório de hemodinâmica com um maior tempo de evolução dos sintomas<a class="elsevierStyleCrossRef" href="#bib0015">3</a>. De facto, o atraso para a reperfusão mecânica é superior nas mulheres devido a um atraso no tempo entre o início dos sintomas e a apresentação ao hospital (o tempo dor‐porta nas mulheres é superior ao dos homens)<a class="elsevierStyleCrossRefs" href="#bib0015">3,4,11</a>. Nas décadas de 50‐60, a doença coronária era conhecida como sendo uma doença do sexo masculino. A partir da década de 70 o aumento da doença coronária no sexo feminino foi atribuído a mudanças no seu estilo de vida, com aumento do tabagismo, o aparecimento da contraceção oral e o aumento da atividade profissional<a class="elsevierStyleCrossRef" href="#bib0060">12</a>. Isto, aliado ao facto de a doença cardiovascular continuar a ser a principal causa de morte na mulher<a class="elsevierStyleCrossRef" href="#bib0005">1</a>, reflete a importância de se desenvolver medidas de sensibilização dedicadas ao sexo feminino para alertar para os reconhecimento dos sintomas do EAM e para focar a necessidade de um pedido de ajuda imediato. O tempo entre os sintomas e a reperfusão mecânica é um dos fatores modificáveis entre os preditores de mau prognóstico.Características do procedimentoRelativamente às características do procedimento de intervenção percutânea também existem algumas diferenças entre géneros. Está descrito que as mulheres têm artérias coronárias de menor diâmetro e que esse facto pode influenciar o tipo de material utilizado, favorecendo o menor uso de stents<a class="elsevierStyleCrossRef" href="#bib0005">1</a>. Isso não se verificou nesta análise do RNCI, sendo semelhante a utilização de stents e o tipo de stent utilizado em ambos os sexos. A redução da reestenose com a generalização do uso de stents revestidos por fármaco parece ser semelhante em ambos os sexos<a class="elsevierStyleCrossRef" href="#bib0065">13</a>. A redução do calibre das artérias, aliada à observação de uma maior tendência para vasoespasmo arterial, pode ser uma explicação para o menor uso do acesso radial no sexo feminino. O sucesso do procedimento de revascularização percutânea é semelhante em ambos os sexos<a class="elsevierStyleCrossRef" href="#bib0070">14</a>, assim como o uso de novos fármacos antitrombóticos<a class="elsevierStyleCrossRef" href="#bib0075">15</a>. Apesar disso, o uso de inibidores das glicoproteínas IIb/IIIa, como fármaco coadjuvante da terapêutica antitrombótica na angioplastia primária, foi muito inferior nas mulheres. O motivo para essa observação pode residir no facto de as mulheres submetidas a intervenção percutânea apresentarem mais complicações hemorrágicas e vasculares, comparativamente aos homens<a class="elsevierStyleCrossRefs" href="#bib0080">16,17</a>. Uma subanálise do ACUITY mostrou que as mulheres apresentaram mais complicações hemorrágicas aos 30 dias do que os homens, sem diferenças na mortalidade a curto e a longo prazo. As mulheres tratadas com bivalirudina tiveram menos complicações hemorrágicas, comparativamente com a estratégia antitrombótica de heparina com inibidores da glicoproteína IIb/IIIa, embora sem diferenças nos eventos isquémicos<a class="elsevierStyleCrossRef" href="#bib0090">18</a>.Existe ainda a evidência do tratamento da doença coronária no sexo feminino diferir do sexo masculino, com mais mulheres com EAMST e idade >65 anos a terem menor acesso à terapêutica de reperfusão<a class="elsevierStyleCrossRef" href="#bib0005">1</a>. No panorama nacional português, nos últimos anos as mulheres tiveram um aumento progressivo de acesso à ICP‐P, aspeto que certamente se reflete na redução da taxa de mortalidade hospitalar do EAMST, observada em ambos os sexos, entre 2002‐2012. Apesar destes avanços conseguidos nos últimos anos no tratamento do EAMST, inclusive no sexo feminino, a mortalidade hospitalar não ajustada continua a ser mais elevada no sexo feminino, convidando à reflexão sobre estratégias que melhorem a estratificação de risco, diagnóstico e terapêutico da doença cardiovascular na mulher.Mortalidade intra‐hospitalarEsta análise do RNCI revela que, na realidade nacional, o género feminino não é um preditor independente de mortalidade hospitalar no contexto de enfarte agudo do miocárdio tratado por ICP‐P. Na análise não ajustada, as mulheres têm pior prognóstico do que os homens. Mas, à semelhança de estudos prévios publicados<a class="elsevierStyleCrossRefs" href="#bib0025">5–7,19,20</a>, após ajustamento estatístico para as comorbilidades e outros fatores prognósticos adversos, o género feminino deixa de ser preditor independente de prognóstico adverso após intervenção percutânea. Este achado foi reprodutível na análise de regressão logística multivariada, assim como na análise ajustada ao propensity score.Na era da trombólise, a sobrevida hospitalar da mulher foi consistentemente inferior à do homem<a class="elsevierStyleCrossRefs" href="#bib0105">21,22</a>, com mais complicações hemorrágicas fatais associadas à terapêutica<a class="elsevierStyleCrossRef" href="#bib0095">19</a>. Num estudo multicêntrico, com 395 doentes (27% mulheres) com EAMST, que comparou a revascularização percutânea com a trombólise, a angioplastia primária foi um preditor independente de sobrevida na mulher<a class="elsevierStyleCrossRef" href="#bib0095">19</a>. Numa subanálise do estudo randomizado GUSTO IIb, ambos os sexos beneficiaram quando submetidos a angioplastia primária comparativamente à trombólise, com menos eventos adversos major a 30 dias, mas o benefício em termos absoluto foi superior nas mulheres (a angioplastia primária preveniu 56 eventos em 1000 nas mulheres versus 42 eventos em 1000 nos homens)<a class="elsevierStyleCrossRef" href="#bib0100">20</a>. A introdução da angioplastia primária como tratamento privilegiado do EAMST, a progressiva melhoria da técnica de intervenção percutânea e das taxas de sucesso do procedimento, assim como os avanços na terapêutica antiagregante e anticoagulante adjuvante, são fatores que podem explicar as diferenças encontradas entre estudos prévios e os atuais. Contudo, alguns estudos atuais que avaliaram diferenças entre géneros no contexto da angioplastia primária, apresentaram resultados diferentes do presente estudo, com o sexo feminino a ser um preditor independente de pior prognóstico a curto prazo, independente da idade e dos fatores de risco cardiovasculares basais<a class="elsevierStyleCrossRefs" href="#bib0015">3,4</a>. Estes estudos sugerem a existência de diferenças fisiopatológicas entre os sexos que podem contribuir para o aumento da mortalidade na mulher com EAMST. Os estrogénios, que nas mulheres as protegem da aterosclerose coronária<a class="elsevierStyleCrossRef" href="#bib0115">23</a>, podem levar ao desenvolvimento de placas vulneráveis menos estenóticas<a class="elsevierStyleCrossRef" href="#bib0120">24</a>. Assim, as mulheres teriam menos circulação colateral e menos capacidade de desenvolver pré‐condicionamento no EAMST, agravando o prognóstico do enfarte<a class="elsevierStyleCrossRefs" href="#bib0125">25,26</a>. Mas este motivo apenas explicaria diferenças encontradas nas mulheres jovens em idade pré‐menopausa. Por outro lado, a presente análise do RNCI, comparativamente aos estudos prévios assinalados<a class="elsevierStyleCrossRefs" href="#bib0015">3,4</a>, apresenta uma amostra de maior dimensão (>7000 doentes tratados por ICP‐P) que agrega dados multicêntricos, refletindo melhor o panorama de um país e não de um centro único, a metodologia estatística é também superior ao incorporar o propensity score, e apresenta dados mais atuais com uma taxa de mortalidade intra‐hospitalar inferior, quer nos homens quer nas mulheres. Numa análise ajustada ao risco, recentemente publicada, em 13 752 doentes (34,6% mulheres), Kovacic et al. clarificaram o facto de o sexo não ser um preditor independente de mortalidade após intervenção percutânea na era dos stents farmacológicos<a class="elsevierStyleCrossRef" href="#bib0135">27</a>, suportando os dados do estudo atual.LimitaçõesO presente estudo é um estudo observacional, não cego, nem randomizado, motivo pelo qual poderá haver fatores de confundimento adicional que podem não ter sido reconhecidos ou contabilizados na análise de risco ajustada. O facto de não haver dados relativamente aos eventos hemorrágicos, sendo um fator de risco independente já conhecido de mortalidade, é outra limitação do presente estudo. O uso da medicação intra‐hospitalar, nomeadamente, antiagregação (com exceção do uso de inibidores IIb/IIIa) e anticoagulação adjuvante não é conhecido, como tal, a possibilidade de haver diferenças na administração destes fármacos entre os sexos não pode ser excluída.ConclusãoNesta amostra do RNCI, as mulheres com EAMST tratadas com ICP‐P apresentaram maior risco cardiovascular, um acesso menos atempado a ICP‐P e um pior prognóstico. Contudo, após ajustamento do risco, o género feminino deixa de ser preditor independente de mortalidade hospitalar.Responsabilidades éticasProteção de pessoas e animaisOs autores declaram que os procedimentos seguidos estavam de acordo com os regulamentos estabelecidos pelos responsáveis da Comissão de Investigação Clínica e Ética e de acordo com os da Associação Médica Mundial e da Declaração de Helsinki.Confidencialidade dos dadosOs autores declaram ter seguido os protocolos de seu centro de trabalho acerca da publicação dos dados de pacientes e que todos os pacientes incluídos no estudo receberam informações suficientes e deram o seu consentimento informado por escrito para participar nesse estudo.Direito à privacidade e consentimento escritoOs autores declaram ter recebido consentimento escrito dos pacientes e/ou sujeitos mencionados no artigo. O autor para correspondência deve estar na posse deste documento.Conflito de interessesOs autores declaram não haver conflito de interesses." "textoCompletoSecciones" => array:1 [ "secciones" => array:14 [ 0 => array:2 [ "identificador" => "xres351728" "titulo" => array:5 [ 0 => "Resumo" 1 => "Objetivos" 2 => "Métodos" 3 => "Resultados" 4 => "Conclusões" ] ] 1 => array:2 [ "identificador" => "xpalclavsec333228" "titulo" => "Palavras‐chave" ] 2 => array:2 [ "identificador" => "xres351729" "titulo" => array:5 [ 0 => "Abstract" 1 => "Aims" 2 => "Methods" 3 => "Results" 4 => "Conclusions" ] ] 3 => array:2 [ "identificador" => "xpalclavsec333227" "titulo" => "Keywords" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introdução" ] 5 => array:3 [ "identificador" => "sec0010" "titulo" => "Métodos" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "População e métodos" ] 1 => array:2 [ "identificador" => "sec0020" "titulo" => "Análise estatística" ] ] ] 6 => array:3 [ "identificador" => "sec0025" "titulo" => "Resultados" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0030" "titulo" => "Características basais" ] 1 => array:2 [ "identificador" => "sec0035" "titulo" => "Características do procedimento" ] 2 => array:2 [ "identificador" => "sec0040" "titulo" => "Preditores da mortalidade hospitalar" ] 3 => array:2 [ "identificador" => "sec0045" "titulo" => "Evolução da mortalidade hospitalar ao longo do período do estudo" ] ] ] 7 => array:3 [ "identificador" => "sec0050" "titulo" => "Discussão" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0055" "titulo" => "Características clínicas e angiográficas" ] 1 => array:2 [ "identificador" => "sec0060" "titulo" => "Características do procedimento" ] 2 => array:2 [ "identificador" => "sec0065" "titulo" => "Mortalidade intra‐hospitalar" ] ] ] 8 => array:2 [ "identificador" => "sec0070" "titulo" => "Limitações" ] 9 => array:2 [ "identificador" => "sec0075" "titulo" => "Conclusão" ] 10 => array:3 [ "identificador" => "sec0080" "titulo" => "Responsabilidades éticas" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0085" "titulo" => "Proteção de pessoas e animais" ] 1 => array:2 [ "identificador" => "sec0090" "titulo" => "Confidencialidade dos dados" ] 2 => array:2 [ "identificador" => "sec0095" "titulo" => "Direito à privacidade e consentimento escrito" ] ] ] 11 => array:2 [ "identificador" => "sec0100" "titulo" => "Conflito de interesses" ] 12 => array:2 [ "identificador" => "xack86799" "titulo" => "Agradecimentos" ] 13 => array:1 [ "titulo" => "Bibliografia" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2013-10-03" "fechaAceptado" => "2013-10-26" "PalabrasClave" => array:2 [ "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras‐chave" "identificador" => "xpalclavsec333228" "palabras" => array:3 [ 0 => "Angioplastia primária" 1 => "Enfarte agudo do miocárdio com supradesnivelamento de ST" 2 => "Sexo feminino" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec333227" "palabras" => array:3 [ 0 => "Primary angioplasty" 1 => "ST‐elevation myocardial infarction" 2 => "Female" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "ObjetivosA mortalidade na mulher após angioplastia primária (ICP‐P) é superior à do homem. Contudo, permanece contraditório o papel do sexo poder ser fator de risco independente para mortalidade no contexto de enfarte agudo do miocárdio com supradesnivelamento de ST (EAMST). Com base no Registo Nacional de Cardiologia de Intervenção (RNCI), pretendemos avaliar como é que o género feminino influencia o prognóstico a curto prazo nos doentes com EAMST submetidos a ICP‐P a nível nacional. MétodosDe 60 158 doentes incluídos prospetivamente no RNCI de 2002‐2012, incluímos na análise 7544 doentes com EAMST tratados por ICP‐P, dos quais 25% foram mulheres. Utilizámos modelos de regressão logística e ajustamento por propensity score para avaliar o impacto do sexo na mortalidade hospitalar. ResultadosAs mulheres foram mais idosas (68±14 versus 61±13, p<0,001), mais diabéticas (30 versus 21%, p<0,001) e hipertensas (69 versus 55%, p<0,001). Os homens foram revascularizados mais cedo (71 versus 63% nas primeiras 6horas, p<0,001). Choque cardiogénico foi mais frequente nas mulheres (7,1 versus 5,7%, p=0,032). Estas apresentaram um pior prognóstico a curto prazo, com 1,7x maior risco de morte intra‐hospitalar (4,3 versus 2,5%; IC 95% 1,30‐2,27; p<0,001). Utilizando um modelo de regressão ajustado através de um propensity score, o sexo deixa de ser preditor de mortalidade hospitalar (OR 1,00; IC 95% 0,68‐1,48; p=1,00). ConclusõesNo RNCI as mulheres com EAMST tratadas com ICP‐P apresentaram maior risco cardiovascular, um acesso menos atempado a ICP‐P e um pior prognóstico. Contudo, após ajustamento do risco, o género feminino deixa de ser preditor independente de mortalidade hospitalar." ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "AimsAlthough mortality after primary percutaneous coronary intervention (PPCI) is higher in women than in men, there is disagreement as to whether gender is an independent risk factor for mortality in ST‐ elevation myocardial infarction (STEMI). Our aim was to assess how gender influenced short‐term prognosis in patients undergoing PPCI in the Portuguese Registry of Interventional Cardiology. MethodsOf 60 158 patients prospectively included in a large registry of contemporary PCI, from 2002 to 2012, we included 7544 patients with STEMI treated by PPCI, of whom 1856 (25%) were female. The effect of gender on in‐hospital mortality was assessed by multivariate logistic regression analysis with propensity score matching. ResultsWomen were older (68±14 vs. 61±13 years, p<0.001), with a higher prevalence of diabetes (30% vs. 21%, p<0.001) and hypertension (69% vs. 55%, p<0.001). Men were more frequently revascularized within six hours of symptom onset (71% vs. 63%, p<0.001). Cardiogenic shock was more frequent in women (7.1% vs. 5.7%, p=0.032). Female gender was associated with a worse short‐term prognosis, with 1.7 times higher risk of in‐hospital death (4.3% in women and 2.5% in men, 95% confidence interval (CI) 1.30‐2.27, p<0.001). After computed propensity score matching based on baseline clinical characteristics, in‐hospital mortality was similar between women and men (odds ratio 1.00, 95% CI 0.68‐1.48, p=1.00). ConclusionsIn the Registry, women with STEMI treated by PPCI had a greater risk‐factor burden, less timely access to treatment and a worse prognosis. However, after risk adjustment, female gender ceases to be an independent predictor of in‐hospital mortality." ] ] "NotaPie" => array:1 [ 0 => array:3 [ "etiqueta" => "1" "nota" => "Sociedade Portuguesa de Cardiologia." "identificador" => "fn1" ] ] "multimedia" => array:8 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1063 "Ancho" => 1584 "Tamanyo" => 102764 ] ] "descripcion" => array:1 [ "pt" => "Preditores de mortalidade hospitalar na angioplastia primária (análise multivariada). BMS: stents metálicos; DAP: doença arterial periférica; DES: stents revestidos por fármaco; ICC: insuficiência cardíaca congestiva." ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figura 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 768 "Ancho" => 1607 "Tamanyo" => 69667 ] ] "descripcion" => array:1 [ "pt" => "Prevalência da angioplastia primária na mulher e no homem ao longo dos anos incluídos no registo nacional de cardiologia de intervenção." ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figura 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 803 "Ancho" => 1593 "Tamanyo" => 77971 ] ] "descripcion" => array:1 [ "pt" => "Evolução da mortalidade hospitalar ao longo do período do estudo em homens e mulheres." ] ] 3 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Tabela 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "Valores apresentados em média±DP ou frequência relativa.AVC: acidente vascular cerebral; CABG: cirurgia de revascularização coronária; CV: cardiovascular; DAP: doença arterial periférica; EAM: enfarte agudo do miocárdio; ICC: insuficiência cardíaca congestiva; ICP: intervenção coronária percutânea; VE: ventricular esquerda." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Mulheres (n=1.856) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Homens (n=5.688) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Valor de p \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Demográficas</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Idade (anos) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">68±14 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">61±13 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Idade >65 anos \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">62,9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">37,4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Fatores de risco CV</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Diabetes mellitus \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">29,6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">20,6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Dislipidemia \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">43,5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">45,4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,164 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hábitos tabágicos \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">21,6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">57,3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hipertensão arterial \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">68,8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">54,8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">História pregressa CV</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">EAM \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10,7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15,3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">ICP \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10,9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15,9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">CABG \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1,9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,008 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">AVC \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6,3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4,4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,003 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">DAP \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2,8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3,0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,676 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">ICC \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3,6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2,4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,013 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Insuficiência renal crónica \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4,0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2,5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,002 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Apresentação clínica à admissão</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Choque cardiogénico \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7,1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5,7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,032 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Fração de ejeção VE ≤40% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">19,1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">17,1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,225 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab526027.png" ] ] ] ] "descripcion" => array:1 [ "pt" => "Características demográficas e apresentação clínica" ] ] 4 => array:7 [ "identificador" => "tbl0010" "etiqueta" => "Tabela 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "Valores apresentados em mediana (P25‐P75) ou frequência relativa.BMS: stents metálicos; DES: stents revestidos por fármaco; ICP: intervenção coronária percutânea." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Mulheres (n=1.856) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Homens (n=5.688) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Valor de p \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Tempos (min)</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Dor‐balão \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">274 (175‐482) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">237 (152‐391) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Dor‐porta \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">260 (160‐452) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">223 (140‐380) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Porta‐balão \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">24 (14‐50) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">22 (14‐47) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,472 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Forma de admissão</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Admissão direta a centro de ICP primária \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">90,6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">88,5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,014 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Transferido de outro hospital \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9,4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">11,5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,014 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Vaso relacionado com o enfarte</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Tronco comum \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1,0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,657 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Descendente anterior \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">36,3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">36,3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,997 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Circunflexa \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13,4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15,1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,078 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Coronária direita \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">49,4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">47,1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,090 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Pontagem \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,007 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Vasos doentes</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Tronco comum \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2,9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3,9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,056 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Descendente anterior \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">71,6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">68,1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,006 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Circunflexa \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">39,6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">43,6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,004 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Coronária direita \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">55,1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">56,9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,192 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Doença coronária multivaso (≥2 vasos) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">47,4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">49,0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,223 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Tipo de lesão</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9,3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9,2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,906 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">B \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">34,5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">33,9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,694 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">C \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">56,3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">56,9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,657 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Reestenose Intrastent \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2,0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2,9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,049 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Tipo de acesso</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Femoral \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">86,0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">82,7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Radial \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13,8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">17,0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Braquial \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1,000 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Angioplastia com stent \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">78,1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">79,9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,110 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Tipo de stent</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">DES \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">44,4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">46,8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,105 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">BMS \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">55,1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">52,9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,141 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Trombectomia \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">22,7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">26,2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,003 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Glicoproteínas IIb/IIIa (abciximab) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">26,7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">35,0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Balão de contrapulsação intra‐aórtico \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3,8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3,0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,122 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Fluxo TIMI 3 à admissão \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">25,0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">21,7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,016 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Fluxo TIMI 3 final \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">92,2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">93,6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,075 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Revascularização completa \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">59,1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">56,1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,028 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab526024.png" ] ] ] ] "descripcion" => array:1 [ "pt" => "Características de procedimento" ] ] 5 => array:7 [ "identificador" => "tbl0015" "etiqueta" => "Tabela 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">OR (IC 95%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Valor de p \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Demográficas</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Sexo feminino \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1,72 (1,30‐2,27) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Idade >65 anos \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3,52 (2,62‐4,73) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Fatores de risco CV</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Diabetes mellitus \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1,79 (1,33‐2,41) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Dislipidemia \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,64 (0,48‐0,87) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,004 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hábitos tabágicos \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,35 (0,26‐0,49) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">História pregressa CV</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">AVC prévio \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1,86 (1,11‐3,09) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,016 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Doença arterial periférica \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3,72 (2,27‐6,12) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Insuficiência cardíaca congestiva prévia \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5,22 (3,25‐8,37) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Insuficiência renal crónica \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2,53 (1,41‐4,53) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Apresentação clínica à admissão</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Choque cardiogénico à admissão \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">17,42 (13,13‐23,12) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Fração de ejeção VE ≤40% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">14,81 (8,31‐26,40) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Enfarte anterior \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2,01 (1,50‐2,69) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Doença tronco comum e/ou multivaso \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1,48 (1,12‐1,95) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,005 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Características do procedimento</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Fluxo TIMI 3 à admissão \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,57 (0,35‐0,93) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,024 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Fluxo TIMI 3 final \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,14 (0,10‐0,21) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Acesso arterial radial \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,24 (0,13‐0,45) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">BMS \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2,88 (1,98‐4,18) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Trombectomia \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,70 (0,50‐0,98) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,038 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Revascularização completa \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,72 (0,55‐0,96) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,023 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab526023.png" ] ] ] ] "descripcion" => array:1 [ "pt" => "Preditores univariáveis de mortalidade hospitalar" ] ] 6 => array:7 [ "identificador" => "tbl0020" "etiqueta" => "Tabela 4" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "CV: cardiovascular; Hx: história; IC: intervalo de confiança; OR: odds ratio; ROC: receiver operating characteristic.Hx CV pregressa inclui fatores de risco CV (diabetes mellitus, hipertensão arterial, dislipidemia e hábitos tabágicos) e história clínica pregressa cardiovascular (história prévia de EAM, revascularização percutânea ou cirúrgica, insuficiência cardíaca congestiva, acidente vascular cerebral, doença arterial periférica e insuficiência renal crónica). Apresentação clínica de gravidade inclui a presença de choque cardiogénico à admissão e EAM de localização anterior. Variáveis do procedimento incluem acesso radial, tipo de stent e trombectomia." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">OR (IC 95%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Valor de p \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Área curva ROC \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Modelo 1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">OR não ajustado \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1,72 (1,30‐2,27) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0,001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Modelo 2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">OR ajustado à idade >65 anos \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1,31 (0,98‐1,74) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,064 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,66 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Modelo 3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">OR ajustado à idade e Hx CV pregressa \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1,07 (0,76‐1,50) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,695 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,74 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Modelo 4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">OR ajustado à idade, Hx CV pregressa e apresentação clínica de gravidade \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1,09 (0,75‐1,57) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,655 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,86 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Modelo 5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">OR ajustado à idade, Hx CV pregressa, apresentação clínica de gravidade e variáveis do procedimento \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1,20 (0,83‐1,73) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,330 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,88 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab526025.png" ] ] ] ] "descripcion" => array:1 [ "pt" => "Mortalidade hospitalar entre homens e mulheres submetidos a ICP primária" ] ] 7 => array:7 [ "identificador" => "tbl0025" "etiqueta" => "Tabela 5" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Ano \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Mulheres (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Homens (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">OR (IC 95%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Valor de p \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2002‐2005 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7,1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4,4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1,68 (0,82‐3,43) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,152 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2005‐2008 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3,4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2,0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1,75 (0,94‐3,25) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,073 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2009‐2012 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4,3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2,5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1,74 (1,23‐2,45) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,002 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab526026.png" ] ] ] ] "descripcion" => array:1 [ "pt" => "Mortalidade hospitalar de acordo com o sexo e ano de admissão" ] ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografia" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:27 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cardiovascular diseases in women: a statement from the policy conference of the European Society of Cardiology" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M. 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Estatísticas

Artigo original

Angioplastia primária na mulher: realidade nacional

Primary angioplasty in women: Data from the Portuguese Registry of Interventional Cardiology

Rita Caléa,

Autor para correspondência

ritacale@hotmail.com

Autor para correspondência.

, Lídia de Sousab, Hélder Pereiraa, Marco Costac, Manuel de Sousa Almeidad, em nome dos Investigadores do Registo Nacional de Cardiologia de Intervenção 1

a Unidade de Cardiologia de Intervenção, Hospital Garcia de Orta, Almada, Portugal

b Unidade de Cardiologia de Intervenção, Centro hospitalar de Lisboa Central, Lisboa, Portugal

c Unidade de Cardiologia de Intervenção, Centro hospitalar de Coimbra, Coimbra, Portugal

d Unidade de Cardiologia de Intervenção, Hospital de Santa Cruz, C.H.L.O., Carnaxide, Portugal

Lido

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tem na mortalidade foi avaliado numa an&#225;lise univari&#225;vel em que se estimou o <span class="elsevierStyleItalic">odds ratio</span> &#40;OR&#41; e respetivo intervalo de confian&#231;a a 95&#37; &#40;IC&#41;&#46; Num primeiro modelo de regress&#227;o considerou&#8208;se unicamente o sexo como vari&#225;vel independente&#46; Posteriormente o impacto do sexo na mortalidade intra&#8208;hospitalar foi ajustado &#224; presen&#231;a de outras vari&#225;veis construindo v&#225;rios modelos de regress&#227;o log&#237;stica&#46; No segundo modelo ajust&#225;mos o impacto do sexo &#224; presen&#231;a de idade &#62;<span class="elsevierStyleHsp" style=""></span>65 anos&#46; No terceiro modelo ajust&#225;mos o impacto do sexo &#224; idade&#44; aos fatores de risco &#40;diabetes <span class="elsevierStyleItalic">mellitus</span>&#44; hipertens&#227;o arterial&#44; dislipidemia e tabagismo&#41; e &#224; hist&#243;ria cl&#237;nica pregressa cardiovascular &#40;hist&#243;ria pr&#233;via de EAM&#44; revasculariza&#231;&#227;o percut&#226;nea ou cir&#250;rgica&#44; insufici&#234;ncia card&#237;aca congestiva&#44; acidente vascular cerebral&#44; doen&#231;a arterial perif&#233;rica e insufici&#234;ncia renal cr&#243;nica&#41;&#46; No quarto modelo consideraram&#8208;se todas as vari&#225;veis do segundo juntamente com as vari&#225;veis cl&#237;nicas de gravidade &#224; admiss&#227;o &#40;presen&#231;a de choque cardiog&#233;nico e EAM de localiza&#231;&#227;o anterior&#41;&#46; O quinto modelo foi ajustado para todas as vari&#225;veis mencionadas previamente e ainda para as caracter&#237;sticas do procedimento &#40;tipo de acesso&#44; tipo de <span class="elsevierStyleItalic">stent</span> e trombectomia&#41;&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">De forma a minimizar a influ&#234;ncia de <span class="elsevierStyleItalic">bias</span> de sele&#231;&#227;o num estudo n&#227;o aleatorizado&#44; uma segunda an&#225;lise foi realizada usando a regress&#227;o log&#237;stica na determina&#231;&#227;o de um <span class="elsevierStyleItalic">score</span> de propens&#227;o&#44; em que se considerou o sexo como vari&#225;vel dependente&#46; O <span class="elsevierStyleItalic">score</span> de propens&#227;o foi usado no emparelhamento de mulheres e homens numa raz&#227;o 1&#58;1&#46; As vari&#225;veis utilizadas no c&#225;lculo do <span class="elsevierStyleItalic">score</span> de propens&#227;o foram&#58; idade&#44; fatores de risco e antecedentes cardiovasculares&#46; Ap&#243;s o emparelhamento dos indiv&#237;duos dos dois sexos&#44; o risco estimado de ocorr&#234;ncia de morte intra&#8208;hospitalar para as mulheres&#44; quando comparadas com os homens&#44; foi ajustado novamente por interm&#233;dio de um modelo de regress&#227;o log&#237;stica em que foram inclu&#237;das as mesmas vari&#225;veis consideradas no quarto modelo descrito acima&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Na constru&#231;&#227;o de todos os modelos de regress&#227;o log&#237;stica referidos na determina&#231;&#227;o dos preditores de morte intra&#8208;hospitalar&#44; o sexo foi for&#231;ado a entrar no modelo ao ser inclu&#237;do no primeiro bloco de vari&#225;veis&#44; enquanto os outros preditores foram selecionados a partir de um segundo bloco de vari&#225;veis&#44; usando o m&#233;todo <span class="elsevierStyleItalic">forward stepwise</span>&#46; A boa calibra&#231;&#227;o dos modelos de regress&#227;o log&#237;stica foi testada pelo teste de Hosmer e Lemeshow&#46; Enquanto as suas capacidades discriminat&#243;rias foram avaliadas a partir das estimativas das respetivas &#225;reas sob a curva ROC&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Foi considerado nesta an&#225;lise o n&#237;vel de signific&#226;ncia de 5&#37;&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">A an&#225;lise estat&#237;stica foi realizada com o <span class="elsevierStyleItalic">software</span> estat&#237;stico SPSS&#44; vers&#227;o 19&#46;0&#46;0&#46;2&#46;</p></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Resultados</span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Caracter&#237;sticas basais</span><p id="par0075" class="elsevierStylePara elsevierViewall">Foram inclu&#237;dos 7544 doentes consecutivos do RNCI submetidos a angioplastia prim&#225;ria no contexto de EAMST&#46; Os doentes foram divididos em dois grupos de acordo com o sexo&#58; 1856 doentes &#40;25&#37;&#41; mulheres e 5688 doentes &#40;75&#37;&#41; homens&#46; As caracter&#237;sticas demogr&#225;ficas basais e a cl&#237;nica de apresenta&#231;&#227;o hospitalar encontram&#8208;se descritas na <a class="elsevierStyleCrossRef" href="#tbl0005">Tabela 1</a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">As mulheres foram mais idosas &#40;68<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>14 <span class="elsevierStyleItalic">versus</span> 61<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41; e apresentaram maior preval&#234;ncia de diabetes &#40;30 <span class="elsevierStyleItalic">versus</span> 21&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; hipertens&#227;o &#40;69 <span class="elsevierStyleItalic">versus</span> 55&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41; e insufici&#234;ncia renal cr&#243;nica &#40;4 <span class="elsevierStyleItalic">versus</span> 2&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;002&#41;&#46; Por outro lado&#44; eram menos fumadoras &#40;22 <span class="elsevierStyleItalic">versus</span> 57&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41; e com menor frequ&#234;ncia apresentaram hist&#243;ria de doen&#231;a coron&#225;ria pr&#233;via como EAM &#40;11 <span class="elsevierStyleItalic">versus</span> 15&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; revasculariza&#231;&#227;o percut&#226;nea &#40;11 <span class="elsevierStyleItalic">versus</span> 16&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41; ou cir&#250;rgica &#40;1 <span class="elsevierStyleItalic">versus</span> 2&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;008&#41;&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">O n&#250;mero de doentes submetidos a ICP&#8208;P que recorreram diretamente a um centro com cardiologia de interven&#231;&#227;o foi superior no sexo feminino &#40;91 <span class="elsevierStyleItalic">versus</span> 89&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;014&#41;&#44; no entanto&#44; esse fator n&#227;o influenciou o tempo porta&#8208;bal&#227;o que foi semelhante em ambos os sexos &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Tabela 2</a>&#41;&#46; Apesar disso&#44; as mulheres foram revascularizadas mais tardiamente &#40;4&#44;6 <span class="elsevierStyleItalic">versus</span> 3&#44;9 horas&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41; porque recorreram mais tarde ao hospital &#40;4&#44;3 <span class="elsevierStyleItalic">versus</span> 3&#44;7 horas&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; A percentagem de homens revascularizados nas primeiras seis horas do in&#237;cio dos sintomas foi superior &#224; das mulheres &#40;71 <span class="elsevierStyleItalic">versus</span> 63&#37;&#44; respetivamente&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">A evolu&#231;&#227;o em choque cardiog&#233;nico foi mais frequente nas mulheres &#40;7&#44;1 <span class="elsevierStyleItalic">versus</span> 5&#44;7&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;032&#41;&#46; N&#227;o houve diferen&#231;as no vaso culp&#225;vel pelo EAM ou na extens&#227;o da doen&#231;a coron&#225;ria&#44; com uma percentagem de doen&#231;a multivaso semelhante em ambos os sexos&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Caracter&#237;sticas do procedimento</span><p id="par0095" class="elsevierStylePara elsevierViewall">As caracter&#237;sticas do procedimento est&#227;o descritas na <a class="elsevierStyleCrossRef" href="#tbl0010">Tabela 2</a>&#46; O acesso vascular usado com maior frequ&#234;ncia em ambos os grupos foi o femoral&#46; O acesso radial foi usado com menor frequ&#234;ncia na mulher &#40;14 <span class="elsevierStyleItalic">versus</span> 17&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; N&#227;o houve diferen&#231;as no tipo de <span class="elsevierStyleItalic">stent</span> usado&#44; mas procedeu&#8208;se a mais trombectomia &#40;23 <span class="elsevierStyleItalic">versus</span> 26&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;003&#41; e administra&#231;&#227;o de inibidores da glicoprote&#237;na <span class="elsevierStyleSmallCaps">II</span>b&#47;<span class="elsevierStyleSmallCaps">III</span>a &#40;27 <span class="elsevierStyleItalic">versus</span> 35&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41; nos homens&#46; A obten&#231;&#227;o de fluxo TIMI 3 no final do procedimento foi tendencialmente mais frequente no sexo masculino&#44; traduzindo um melhor resultado angiogr&#225;fico&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Preditores da mortalidade hospitalar</span><p id="par0100" class="elsevierStylePara elsevierViewall">A mortalidade hospitalar foi superior nas mulheres &#40;4&#44;3 <span class="elsevierStyleItalic">versus</span> 2&#44;5&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; Estimou&#8208;se que o risco de ocorr&#234;ncia de morte no sexo feminino seja 1&#44;7 vezes superior ao risco no sexo masculino &#40;IC 95&#37;&#58; 1&#44;30&#8208;2&#44;27&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Tabela 3</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0105" class="elsevierStylePara elsevierViewall">Ap&#243;s ajuste para a idade &#62;<span class="elsevierStyleHsp" style=""></span>65 anos&#44; verifica&#8208;se que este fator contribuiu largamente para explicar o excesso de risco das mulheres comparativamente aos homens &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">Tabela 4</a>&#41;&#46; A partir da an&#225;lise multivari&#225;vel &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figura 1</a>&#41;&#44; os preditores independentes para a ocorr&#234;ncia de morte intra&#8208;hospitalar foram a idade &#62;<span class="elsevierStyleHsp" style=""></span>65 anos&#44; a doen&#231;a arterial perif&#233;rica&#44; antecedentes de insufici&#234;ncia card&#237;aca congestiva&#44; evolu&#231;&#227;o em choque cardiog&#233;nico e enfarte anterior&#46; A presen&#231;a de dislipidemia&#44; o uso de <span class="elsevierStyleItalic">stents</span> revestidos por f&#225;rmaco e o acesso radial foram vari&#225;veis protetoras&#46; A &#225;rea sob a curva ROC no modelo final foi de 0&#44;88&#44; o que traduz a excelente capacidade de discrimina&#231;&#227;o do modelo obtido&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0110" class="elsevierStylePara elsevierViewall">A partir de um modelo de regress&#227;o log&#237;stica&#44; que considerou o sexo como vari&#225;vel dependente&#44; determinou&#8208;se um <span class="elsevierStyleItalic">propensity score</span> que posteriormente foi usado no emparelhamento de 1338 mulheres e 1338 homens&#44; numa raz&#227;o 1&#58;1&#46; Ap&#243;s ajuste usando este modelo estat&#237;stico&#44; a mortalidade intra&#8208;hospitalar entre mulheres e homens foi semelhante na ordem dos 3&#44;9&#37; &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;00&#59; IC 95&#37;&#58; 0&#44;68&#8208;1&#44;48&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;00&#41;&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Evolu&#231;&#227;o da mortalidade hospitalar ao longo do per&#237;odo do estudo</span><p id="par0115" class="elsevierStylePara elsevierViewall">A preval&#234;ncia da ICP&#8208;P nas mulheres no RNCI tem vindo a crescer de forma linear ao longo dos anos &#40;11&#37; de 2002&#8208;2005 <span class="elsevierStyleItalic">versus</span> 15&#37; de 2006 a 2008 <span class="elsevierStyleItalic">versus</span> 19&#37; de 2009 a 2012&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001 para a tend&#234;ncia&#41;&#44; semelhante ao observado nos homens &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figura 2</a>&#41;&#46; Ao longo dos anos inclu&#237;dos no estudo a mortalidade hospitalar das mulheres foi sempre superior comparativamente com os homens&#44; com diferen&#231;as que se acentuaram nos &#250;ltimos anos &#40;<a class="elsevierStyleCrossRef" href="#tbl0025">Tabela 5</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0025"></elsevierMultimedia><p id="par0120" class="elsevierStylePara elsevierViewall">Embora a taxa de mortalidade hospitalar tenha diminu&#237;do em termos absolutos em ambos os sexos&#44; entre 2002&#8208;2012&#44; essa redu&#231;&#227;o s&#243; foi significativa nos homens &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Figura 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Discuss&#227;o</span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Caracter&#237;sticas cl&#237;nicas e angiogr&#225;ficas</span><p id="par0125" class="elsevierStylePara elsevierViewall">&#192; semelhan&#231;a de muitos outros estudos de revasculariza&#231;&#227;o coron&#225;ria&#44; em ambos os contextos de cirurgia de revasculariza&#231;&#227;o coron&#225;ria e de interven&#231;&#227;o percut&#226;nea&#44; a apresenta&#231;&#227;o cl&#237;nica da doen&#231;a coron&#225;ria varia entre os sexos<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#8211;6&#44;8&#44;9</span></a>&#46; A mulher tem uma apresenta&#231;&#227;o da s&#237;ndrome coron&#225;ria aguda numa idade mais avan&#231;ada&#44; em m&#233;dia uma d&#233;cada mais tarde&#44; e mais frequentemente t&#234;m queixas at&#237;picas em detrimento da angina cl&#225;ssica&#46; As mulheres t&#234;m um pior perfil cardiovascular com maior preval&#234;ncia de diabetes <span class="elsevierStyleItalic">mellitus</span> e hipertens&#227;o arterial&#46; A acumula&#231;&#227;o de fatores de risco cardiovasculares &#233; comum na mulher em idade p&#243;s&#8208;menopausa<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">Apesar do elevado perfil de risco da mulher submetida a angioplastia prim&#225;ria&#44; a extens&#227;o da doen&#231;a coron&#225;ria &#233; semelhante &#224; do homem&#44; com uma preval&#234;ncia semelhante de doen&#231;a multivaso<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a>&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">A incid&#234;ncia de insufici&#234;ncia card&#237;aca congestiva e de choque cardiog&#233;nico na admiss&#227;o hospitalar &#233; significativamente superior na mulher&#44; apesar de terem menos hist&#243;ria pr&#233;via de enfarte do mioc&#225;rdio e apresentarem uma fun&#231;&#227;o ventricular esquerda semelhante&#46; Esta observa&#231;&#227;o &#233; similar a muitos outros estudos<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4&#44;9</span></a>&#46; A maior preval&#234;ncia de disfun&#231;&#227;o diast&#243;lica devido &#224; idade avan&#231;ada e &#224; cardiopatia hipertensiva&#44; tem sido a explica&#231;&#227;o mais frequentemente proposta<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a>&#46; Um mioc&#225;rdio hipertrofiado pode ser menos tolerante a per&#237;odos isqu&#233;micos transit&#243;rios&#46; A diminui&#231;&#227;o da <span class="elsevierStyleItalic">compliance</span> diast&#243;lica que ocorre ap&#243;s oclus&#227;o abrupta de vaso pode ser menos bem tolerada em doentes com hipertrofia ventricular esquerda<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a>&#46; Por outro lado&#44; a maior incid&#234;ncia de instabilidade hemodin&#226;mica &#224; admiss&#227;o pode ser explicada pelo facto de as mulheres chegarem ao laborat&#243;rio de hemodin&#226;mica com um maior tempo de evolu&#231;&#227;o dos sintomas<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a>&#46; De facto&#44; o atraso para a reperfus&#227;o mec&#226;nica &#233; superior nas mulheres devido a um atraso no tempo entre o in&#237;cio dos sintomas e a apresenta&#231;&#227;o ao hospital &#40;o tempo dor&#8208;porta nas mulheres &#233; superior ao dos homens&#41;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4&#44;11</span></a>&#46; Nas d&#233;cadas de 50&#8208;60&#44; a doen&#231;a coron&#225;ria era conhecida como sendo uma doen&#231;a do sexo masculino&#46; A partir da d&#233;cada de 70 o aumento da doen&#231;a coron&#225;ria no sexo feminino foi atribu&#237;do a mudan&#231;as no seu estilo de vida&#44; com aumento do tabagismo&#44; o aparecimento da contrace&#231;&#227;o oral e o aumento da atividade profissional<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a>&#46; Isto&#44; aliado ao facto de a doen&#231;a cardiovascular continuar a ser a principal causa de morte na mulher<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>&#44; reflete a import&#226;ncia de se desenvolver medidas de sensibiliza&#231;&#227;o dedicadas ao sexo feminino para alertar para os reconhecimento dos sintomas do EAM e para focar a necessidade de um pedido de ajuda imediato&#46; O tempo entre os sintomas e a reperfus&#227;o mec&#226;nica &#233; um dos fatores modific&#225;veis entre os preditores de mau progn&#243;stico&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Caracter&#237;sticas do procedimento</span><p id="par0140" class="elsevierStylePara elsevierViewall">Relativamente &#224;s caracter&#237;sticas do procedimento de interven&#231;&#227;o percut&#226;nea tamb&#233;m existem algumas diferen&#231;as entre g&#233;neros&#46; Est&#225; descrito que as mulheres t&#234;m art&#233;rias coron&#225;rias de menor di&#226;metro e que esse facto pode influenciar o tipo de material utilizado&#44; favorecendo o menor uso de <span class="elsevierStyleItalic">stents</span><a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>&#46; Isso n&#227;o se verificou nesta an&#225;lise do RNCI&#44; sendo semelhante a utiliza&#231;&#227;o de <span class="elsevierStyleItalic">stents</span> e o tipo de <span class="elsevierStyleItalic">stent</span> utilizado em ambos os sexos&#46; A redu&#231;&#227;o da reestenose com a generaliza&#231;&#227;o do uso de <span class="elsevierStyleItalic">stents</span> revestidos por f&#225;rmaco parece ser semelhante em ambos os sexos<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a>&#46; A redu&#231;&#227;o do calibre das art&#233;rias&#44; aliada &#224; observa&#231;&#227;o de uma maior tend&#234;ncia para vasoespasmo arterial&#44; pode ser uma explica&#231;&#227;o para o menor uso do acesso radial no sexo feminino&#46; O sucesso do procedimento de revasculariza&#231;&#227;o percut&#226;nea &#233; semelhante em ambos os sexos<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a>&#44; assim como o uso de novos f&#225;rmacos antitromb&#243;ticos<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a>&#46; Apesar disso&#44; o uso de inibidores das glicoprote&#237;nas <span class="elsevierStyleSmallCaps">II</span>b&#47;<span class="elsevierStyleSmallCaps">III</span>a&#44; como f&#225;rmaco coadjuvante da terap&#234;utica antitromb&#243;tica na angioplastia prim&#225;ria&#44; foi muito inferior nas mulheres&#46; O motivo para essa observa&#231;&#227;o pode residir no facto de as mulheres submetidas a interven&#231;&#227;o percut&#226;nea apresentarem mais complica&#231;&#245;es hemorr&#225;gicas e vasculares&#44; comparativamente aos homens<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">16&#44;17</span></a>&#46; Uma suban&#225;lise do ACUITY mostrou que as mulheres apresentaram mais complica&#231;&#245;es hemorr&#225;gicas aos 30 dias do que os homens&#44; sem diferen&#231;as na mortalidade a curto e a longo prazo&#46; As mulheres tratadas com bivalirudina tiveram menos complica&#231;&#245;es hemorr&#225;gicas&#44; comparativamente com a estrat&#233;gia antitromb&#243;tica de heparina com inibidores da glicoprote&#237;na <span class="elsevierStyleSmallCaps">II</span>b&#47;<span class="elsevierStyleSmallCaps">III</span>a&#44; embora sem diferen&#231;as nos eventos isqu&#233;micos<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a>&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Existe ainda a evid&#234;ncia do tratamento da doen&#231;a coron&#225;ria no sexo feminino diferir do sexo masculino&#44; com mais mulheres com EAMST e idade &#62;<span class="elsevierStyleHsp" style=""></span>65 anos a terem menor acesso &#224; terap&#234;utica de reperfus&#227;o<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>&#46; No panorama nacional portugu&#234;s&#44; nos &#250;ltimos anos as mulheres tiveram um aumento progressivo de acesso &#224; ICP&#8208;P&#44; aspeto que certamente se reflete na redu&#231;&#227;o da taxa de mortalidade hospitalar do EAMST&#44; observada em ambos os sexos&#44; entre 2002&#8208;2012&#46; Apesar destes avan&#231;os conseguidos nos &#250;ltimos anos no tratamento do EAMST&#44; inclusive no sexo feminino&#44; a mortalidade hospitalar n&#227;o ajustada continua a ser mais elevada no sexo feminino&#44; convidando &#224; reflex&#227;o sobre estrat&#233;gias que melhorem a estratifica&#231;&#227;o de risco&#44; diagn&#243;stico e terap&#234;utico da doen&#231;a cardiovascular na mulher&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Mortalidade intra&#8208;hospitalar</span><p id="par0150" class="elsevierStylePara elsevierViewall">Esta an&#225;lise do RNCI revela que&#44; na realidade nacional&#44; o g&#233;nero feminino n&#227;o &#233; um preditor independente de mortalidade hospitalar no contexto de enfarte agudo do mioc&#225;rdio tratado por ICP&#8208;P&#46; Na an&#225;lise n&#227;o ajustada&#44; as mulheres t&#234;m pior progn&#243;stico do que os homens&#46; Mas&#44; &#224; semelhan&#231;a de estudos pr&#233;vios publicados<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#8211;7&#44;19&#44;20</span></a>&#44; ap&#243;s ajustamento estat&#237;stico para as comorbilidades e outros fatores progn&#243;sticos adversos&#44; o g&#233;nero feminino deixa de ser preditor independente de progn&#243;stico adverso ap&#243;s interven&#231;&#227;o percut&#226;nea&#46; Este achado foi reprodut&#237;vel na an&#225;lise de regress&#227;o log&#237;stica multivariada&#44; assim como na an&#225;lise ajustada ao <span class="elsevierStyleItalic">propensity score</span>&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">Na era da tromb&#243;lise&#44; a sobrevida hospitalar da mulher foi consistentemente inferior &#224; do homem<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">21&#44;22</span></a>&#44; com mais complica&#231;&#245;es hemorr&#225;gicas fatais associadas &#224; terap&#234;utica<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a>&#46; Num estudo multic&#234;ntrico&#44; com 395 doentes &#40;27&#37; mulheres&#41; com EAMST&#44; que comparou a revasculariza&#231;&#227;o percut&#226;nea com a tromb&#243;lise&#44; a angioplastia prim&#225;ria foi um preditor independente de sobrevida na mulher<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a>&#46; Numa suban&#225;lise do estudo randomizado GUSTO <span class="elsevierStyleSmallCaps">II</span>b&#44; ambos os sexos beneficiaram quando submetidos a angioplastia prim&#225;ria comparativamente &#224; tromb&#243;lise&#44; com menos eventos adversos <span class="elsevierStyleItalic">major</span> a 30 dias&#44; mas o benef&#237;cio em termos absoluto foi superior nas mulheres &#40;a angioplastia prim&#225;ria preveniu 56 eventos em 1000 nas mulheres <span class="elsevierStyleItalic">versus</span> 42 eventos em 1000 nos homens&#41;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a>&#46; A introdu&#231;&#227;o da angioplastia prim&#225;ria como tratamento privilegiado do EAMST&#44; a progressiva melhoria da t&#233;cnica de interven&#231;&#227;o percut&#226;nea e das taxas de sucesso do procedimento&#44; assim como os avan&#231;os na terap&#234;utica antiagregante e anticoagulante adjuvante&#44; s&#227;o fatores que podem explicar as diferen&#231;as encontradas entre estudos pr&#233;vios e os atuais&#46; Contudo&#44; alguns estudos atuais que avaliaram diferen&#231;as entre g&#233;neros no contexto da angioplastia prim&#225;ria&#44; apresentaram resultados diferentes do presente estudo&#44; com o sexo feminino a ser um preditor independente de pior progn&#243;stico a curto prazo&#44; independente da idade e dos fatores de risco cardiovasculares basais<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4</span></a>&#46; Estes estudos sugerem a exist&#234;ncia de diferen&#231;as fisiopatol&#243;gicas entre os sexos que podem contribuir para o aumento da mortalidade na mulher com EAMST&#46; Os estrog&#233;nios&#44; que nas mulheres as protegem da aterosclerose coron&#225;ria<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a>&#44; podem levar ao desenvolvimento de placas vulner&#225;veis menos esten&#243;ticas<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a>&#46; Assim&#44; as mulheres teriam menos circula&#231;&#227;o colateral e menos capacidade de desenvolver pr&#233;&#8208;condicionamento no EAMST&#44; agravando o progn&#243;stico do enfarte<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">25&#44;26</span></a>&#46; Mas este motivo apenas explicaria diferen&#231;as encontradas nas mulheres jovens em idade pr&#233;&#8208;menopausa&#46; Por outro lado&#44; a presente an&#225;lise do RNCI&#44; comparativamente aos estudos pr&#233;vios assinalados<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4</span></a>&#44; apresenta uma amostra de maior dimens&#227;o &#40;&#62;<span class="elsevierStyleHsp" style=""></span>7000 doentes tratados por ICP&#8208;P&#41; que agrega dados multic&#234;ntricos&#44; refletindo melhor o panorama de um pa&#237;s e n&#227;o de um centro &#250;nico&#44; a metodologia estat&#237;stica &#233; tamb&#233;m superior ao incorporar o <span class="elsevierStyleItalic">propensity score</span>&#44; e apresenta dados mais atuais com uma taxa de mortalidade intra&#8208;hospitalar inferior&#44; quer nos homens quer nas mulheres&#46; Numa an&#225;lise ajustada ao risco&#44; recentemente publicada&#44; em 13 752 doentes &#40;34&#44;6&#37; mulheres&#41;&#44; Kovacic et al&#46; clarificaram o facto de o sexo n&#227;o ser um preditor independente de mortalidade ap&#243;s interven&#231;&#227;o percut&#226;nea na era dos <span class="elsevierStyleItalic">stents</span> farmacol&#243;gicos<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">27</span></a>&#44; suportando os dados do estudo atual&#46;</p></span></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Limita&#231;&#245;es</span><p id="par0160" class="elsevierStylePara elsevierViewall">O presente estudo &#233; um estudo observacional&#44; n&#227;o cego&#44; nem randomizado&#44; motivo pelo qual poder&#225; haver fatores de confundimento adicional que podem n&#227;o ter sido reconhecidos ou contabilizados na an&#225;lise de risco ajustada&#46; O facto de n&#227;o haver dados relativamente aos eventos hemorr&#225;gicos&#44; sendo um fator de risco independente j&#225; conhecido de mortalidade&#44; &#233; outra limita&#231;&#227;o do presente estudo&#46; O uso da medica&#231;&#227;o intra&#8208;hospitalar&#44; nomeadamente&#44; antiagrega&#231;&#227;o &#40;com exce&#231;&#227;o do uso de inibidores <span class="elsevierStyleSmallCaps">II</span>b&#47;<span class="elsevierStyleSmallCaps">III</span>a&#41; e anticoagula&#231;&#227;o adjuvante n&#227;o &#233; conhecido&#44; como tal&#44; a possibilidade de haver diferen&#231;as na administra&#231;&#227;o destes f&#225;rmacos entre os sexos n&#227;o pode ser exclu&#237;da&#46;</p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Conclus&#227;o</span><p id="par0165" class="elsevierStylePara elsevierViewall">Nesta amostra do RNCI&#44; as mulheres com EAMST tratadas com ICP&#8208;P apresentaram maior risco cardiovascular&#44; um acesso menos atempado a ICP&#8208;P e um pior progn&#243;stico&#46; Contudo&#44; ap&#243;s ajustamento do risco&#44; o g&#233;nero feminino deixa de ser preditor independente de mortalidade hospitalar&#46;</p></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Responsabilidades &#233;ticas</span><span id="sec0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0145">Prote&#231;&#227;o de pessoas e animais</span><p id="par0170" class="elsevierStylePara elsevierViewall">Os autores declaram que os procedimentos seguidos estavam de acordo com os regulamentos estabelecidos pelos respons&#225;veis da Comiss&#227;o de Investiga&#231;&#227;o Cl&#237;nica e &#201;tica e de acordo com os da Associa&#231;&#227;o M&#233;dica Mundial e da Declara&#231;&#227;o de Helsinki&#46;</p></span><span id="sec0090" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0150">Confidencialidade dos dados</span><p id="par0175" class="elsevierStylePara elsevierViewall">Os autores declaram ter seguido os protocolos de seu centro de trabalho acerca da publica&#231;&#227;o dos dados de pacientes e que todos os pacientes inclu&#237;dos no estudo receberam informa&#231;&#245;es suficientes e deram o seu consentimento informado por escrito para participar nesse estudo&#46;</p></span><span id="sec0095" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0155">Direito &#224; privacidade e consentimento escrito</span><p id="par0180" class="elsevierStylePara elsevierViewall">Os autores declaram ter recebido consentimento escrito dos pacientes e&#47;ou sujeitos mencionados no artigo&#46; O autor para correspond&#234;ncia deve estar na posse deste documento&#46;</p></span></span><span id="sec0100" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0160">Conflito de interesses</span><p id="par0185" class="elsevierStylePara elsevierViewall">Os autores declaram n&#227;o haver conflito de interesses&#46;</p></span></span>"
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        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0010">Objetivos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A mortalidade na mulher ap&#243;s angioplastia prim&#225;ria &#40;ICP&#8208;P&#41; &#233; superior &#224; do homem&#46; Contudo&#44; permanece contradit&#243;rio o papel do sexo poder ser fator de risco independente para mortalidade no contexto de enfarte agudo do mioc&#225;rdio com supradesnivelamento de ST &#40;EAMST&#41;&#46; Com base no Registo Nacional de Cardiologia de Interven&#231;&#227;o &#40;RNCI&#41;&#44; pretendemos avaliar como &#233; que o g&#233;nero feminino influencia o progn&#243;stico a curto prazo nos doentes com EAMST submetidos a ICP&#8208;P a n&#237;vel nacional&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0015">M&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">De 60 158 doentes inclu&#237;dos prospetivamente no RNCI de 2002&#8208;2012&#44; inclu&#237;mos na an&#225;lise 7544 doentes com EAMST tratados por ICP&#8208;P&#44; dos quais 25&#37; foram mulheres&#46; Utiliz&#225;mos modelos de regress&#227;o log&#237;stica e ajustamento por <span class="elsevierStyleItalic">propensity score</span> para avaliar o impacto do sexo na mortalidade hospitalar&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0020">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">As mulheres foram mais idosas &#40;68<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>14 <span class="elsevierStyleItalic">versus</span> 61<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; mais diab&#233;ticas &#40;30 <span class="elsevierStyleItalic">versus</span> 21&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41; e hipertensas &#40;69 <span class="elsevierStyleItalic">versus</span> 55&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; Os homens foram revascularizados mais cedo &#40;71 <span class="elsevierStyleItalic">versus</span> 63&#37; nas primeiras 6<span class="elsevierStyleHsp" style=""></span>horas&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; Choque cardiog&#233;nico foi mais frequente nas mulheres &#40;7&#44;1 <span class="elsevierStyleItalic">versus</span> 5&#44;7&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;032&#41;&#46; Estas apresentaram um pior progn&#243;stico a curto prazo&#44; com 1&#44;7<span class="elsevierStyleHsp" style=""></span>x maior risco de morte intra&#8208;hospitalar &#40;4&#44;3 <span class="elsevierStyleItalic">versus</span> 2&#44;5&#37;&#59; IC 95&#37; 1&#44;30&#8208;2&#44;27&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; Utilizando um modelo de regress&#227;o ajustado atrav&#233;s de um <span class="elsevierStyleItalic">propensity score</span>&#44; o sexo deixa de ser preditor de mortalidade hospitalar &#40;OR 1&#44;00&#59; IC 95&#37; 0&#44;68&#8208;1&#44;48&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;00&#41;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0025">Conclus&#245;es</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">No RNCI as mulheres com EAMST tratadas com ICP&#8208;P apresentaram maior risco cardiovascular&#44; um acesso menos atempado a ICP&#8208;P e um pior progn&#243;stico&#46; Contudo&#44; ap&#243;s ajustamento do risco&#44; o g&#233;nero feminino deixa de ser preditor independente de mortalidade hospitalar&#46;</p>"
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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0035">Aims</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Although mortality after primary percutaneous coronary intervention &#40;PPCI&#41; is higher in women than in men&#44; there is disagreement as to whether gender is an independent risk factor for mortality in ST&#8208; elevation myocardial infarction &#40;STEMI&#41;&#46; Our aim was to assess how gender influenced short&#8208;term prognosis in patients undergoing PPCI in the Portuguese Registry of Interventional Cardiology&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0040">Methods</span><p id="spar0120" class="elsevierStyleSimplePara elsevierViewall">Of 60 158 patients prospectively included in a large registry of contemporary PCI&#44; from 2002 to 2012&#44; we included 7544 patients with STEMI treated by PPCI&#44; of whom 1856 &#40;25&#37;&#41; were female&#46; The effect of gender on in&#8208;hospital mortality was assessed by multivariate logistic regression analysis with propensity score matching&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0045">Results</span><p id="spar0125" class="elsevierStyleSimplePara elsevierViewall">Women were older &#40;68&#177;14 vs&#46; 61&#177;13 years&#44; p&#60;0&#46;001&#41;&#44; with a higher prevalence of diabetes &#40;30&#37; vs&#46; 21&#37;&#44; p&#60;0&#46;001&#41; and hypertension &#40;69&#37; vs&#46; 55&#37;&#44; p&#60;0&#46;001&#41;&#46; Men were more frequently revascularized within six hours of symptom onset &#40;71&#37; vs&#46; 63&#37;&#44; p&#60;0&#46;001&#41;&#46; Cardiogenic shock was more frequent in women &#40;7&#46;1&#37; vs&#46; 5&#46;7&#37;&#44; p&#61;0&#46;032&#41;&#46; Female gender was associated with a worse short&#8208;term prognosis&#44; with 1&#46;7 times higher risk of in&#8208;hospital death &#40;4&#46;3&#37; in women and 2&#46;5&#37; in men&#44; 95&#37; confidence interval &#40;CI&#41; 1&#46;30&#8208;2&#46;27&#44; p&#60;0&#46;001&#41;&#46; After computed propensity score matching based on baseline clinical characteristics&#44; in&#8208;hospital mortality was similar between women and men &#40;odds ratio 1&#46;00&#44; 95&#37; CI 0&#46;68&#8208;1&#46;48&#44; p&#61;1&#46;00&#41;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0050">Conclusions</span><p id="spar0130" class="elsevierStyleSimplePara elsevierViewall">In the Registry&#44; women with STEMI treated by PPCI had a greater risk&#8208;factor burden&#44; less timely access to treatment and a worse prognosis&#46; However&#44; after risk adjustment&#44; female gender ceases to be an independent predictor of in&#8208;hospital mortality&#46;</p>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Sociedade Portuguesa de Cardiologia&#46;</p>"
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        "etiqueta" => "Figura 1"
        "tipo" => "MULTIMEDIAFIGURA"
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        "mostrarDisplay" => false
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          "pt" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Preditores de mortalidade hospitalar na angioplastia prim&#225;ria &#40;an&#225;lise multivariada&#41;&#46;</p> <p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">BMS&#58; <span class="elsevierStyleItalic">stents</span> met&#225;licos&#59; DAP&#58; doen&#231;a arterial perif&#233;rica&#59; DES&#58; <span class="elsevierStyleItalic">stents</span> revestidos por f&#225;rmaco&#59; ICC&#58; insufici&#234;ncia card&#237;aca congestiva&#46;</p>"
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      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figura 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 768
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          "pt" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Preval&#234;ncia da angioplastia prim&#225;ria na mulher e no homem ao longo dos anos inclu&#237;dos no registo nacional de cardiologia de interven&#231;&#227;o&#46;</p>"
        ]
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      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figura 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
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          "pt" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Evolu&#231;&#227;o da mortalidade hospitalar ao longo do per&#237;odo do estudo em homens e mulheres&#46;</p>"
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        "tipo" => "MULTIMEDIATABLA"
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        "tabla" => array:2 [
          "leyenda" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Valores apresentados em m&#233;dia<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DP ou frequ&#234;ncia relativa&#46;</p><p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">AVC&#58; acidente vascular cerebral&#59; CABG&#58; cirurgia de revasculariza&#231;&#227;o coron&#225;ria&#59; CV&#58; cardiovascular&#59; DAP&#58; doen&#231;a arterial perif&#233;rica&#59; EAM&#58; enfarte agudo do mioc&#225;rdio&#59; ICC&#58; insufici&#234;ncia card&#237;aca congestiva&#59; ICP&#58; interven&#231;&#227;o coron&#225;ria percut&#226;nea&#59; VE&#58; ventricular esquerda&#46;</p>"
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                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">61<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Idade &#62;<span class="elsevierStyleHsp" style=""></span>65 anos&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">62&#44;9&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">37&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " colspan="4" align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">29&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Dislipidemia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">43&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">45&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">0&#44;164&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>H&#225;bitos tab&#225;gicos&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">21&#44;6&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">57&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hipertens&#227;o arterial&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">68&#44;8&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">54&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Hist&#243;ria pregressa CV</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>EAM&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>ICP&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>CABG&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;008&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>AVC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;003&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Insufici&#234;ncia renal cr&#243;nica&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Tronco comum&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Descendente anterior&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">36&#44;3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Circunflexa&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">15&#44;1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;078&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Coron&#225;ria direita&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">49&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">47&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#44;090&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Pontagem&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">0&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Vasos doentes</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Tronco comum&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">2&#44;9&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">3&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">0&#44;056&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Descendente anterior&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">71&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">68&#44;1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;006&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Circunflexa&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">39&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">43&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#44;004&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Coron&#225;ria direita&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">55&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">56&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;192&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Doen&#231;a coron&#225;ria multivaso &#40;&#8805;<span class="elsevierStyleHsp" style=""></span>2 vasos&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">47&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">49&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#44;223&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Tipo de les&#227;o</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">A</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#44;906&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">B</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">34&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">33&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;694&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">C</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">56&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">56&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;657&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Reestenose <span class="elsevierStyleItalic">Intrastent</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;049&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Tipo de acesso</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Femoral&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">86&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">82&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Radial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">13&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Braquial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Angioplastia com stent</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">78&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">79&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;110&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Tipo de stent</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>DES&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">44&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">46&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;105&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Apresenta&#231;&#227;o cl&#237;nica &#224; admiss&#227;o</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Choque cardiog&#233;nico &#224; admiss&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&#44;42 &#40;13&#44;13&#8208;23&#44;12&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Fra&#231;&#227;o de eje&#231;&#227;o VE &#8804;<span class="elsevierStyleHsp" style=""></span>40&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&#44;81 &#40;8&#44;31&#8208;26&#44;40&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Enfarte anterior&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;01 &#40;1&#44;50&#8208;2&#44;69&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Doen&#231;a tronco comum e&#47;ou multivaso&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;48 &#40;1&#44;12&#8208;1&#44;95&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Caracter&#237;sticas do procedimento</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Fluxo TIMI 3 &#224; admiss&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;57 &#40;0&#44;35&#8208;0&#44;93&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;024&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Fluxo TIMI 3 final&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;14 &#40;0&#44;10&#8208;0&#44;21&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Acesso arterial radial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;24 &#40;0&#44;13&#8208;0&#44;45&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>BMS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;88 &#40;1&#44;98&#8208;4&#44;18&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Trombectomia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;70 &#40;0&#44;50&#8208;0&#44;98&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;038&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Revasculariza&#231;&#227;o completa&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;72 &#40;0&#44;55&#8208;0&#44;96&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;023&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "leyenda" => "<p id="spar0105" class="elsevierStyleSimplePara elsevierViewall">CV&#58; cardiovascular&#59; Hx&#58; hist&#243;ria&#59; IC&#58; intervalo de confian&#231;a&#59; OR&#58; <span class="elsevierStyleItalic">odds ratio&#59;</span> ROC&#58; <span class="elsevierStyleItalic">receiver operating characteristic&#46;</span></p><p id="spar0110" class="elsevierStyleSimplePara elsevierViewall">Hx CV pregressa inclui fatores de risco CV &#40;diabetes <span class="elsevierStyleItalic">mellitus</span>&#44; hipertens&#227;o arterial&#44; dislipidemia e h&#225;bitos tab&#225;gicos&#41; e hist&#243;ria cl&#237;nica pregressa cardiovascular &#40;hist&#243;ria pr&#233;via de EAM&#44; revasculariza&#231;&#227;o percut&#226;nea ou cir&#250;rgica&#44; insufici&#234;ncia card&#237;aca congestiva&#44; acidente vascular cerebral&#44; doen&#231;a arterial perif&#233;rica e insufici&#234;ncia renal cr&#243;nica&#41;&#46; Apresenta&#231;&#227;o cl&#237;nica de gravidade inclui a presen&#231;a de choque cardiog&#233;nico &#224; admiss&#227;o e EAM de localiza&#231;&#227;o anterior&#46; Vari&#225;veis do procedimento incluem acesso radial&#44; tipo de <span class="elsevierStyleItalic">stent</span> e trombectomia&#46;</p>"
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">OR &#40;IC 95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Valor de p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&#193;rea curva ROC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Modelo 1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">OR n&#227;o ajustado&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;72 &#40;1&#44;30&#8208;2&#44;27&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Modelo 2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">OR ajustado &#224; idade &#62;<span class="elsevierStyleHsp" style=""></span>65 anos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;31 &#40;0&#44;98&#8208;1&#44;74&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;064&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;66&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Modelo 3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">OR ajustado &#224; idade e Hx CV pregressa&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;07 &#40;0&#44;76&#8208;1&#44;50&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;695&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;74&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Modelo 4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">OR ajustado &#224; idade&#44; Hx CV pregressa e apresenta&#231;&#227;o cl&#237;nica de gravidade&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;09 &#40;0&#44;75&#8208;1&#44;57&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;655&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;86&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Modelo 5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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Informação do artigo

ISSN: 08702551
Idioma original: Português

DOI:10.1016/j.repc.2013.10.010

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2019 Novembro	25	6	31
2019 Outubro	33	2	35
2019 Setembro	50	8	58
2019 Agosto	36	3	39
2019 Julho	36	14	50
2019 Junho	34	7	41
2019 Maio	28	6	34
2019 Abril	31	12	43
2019 Mar�o	97	11	108
2019 Fevereiro	70	11	81
2019 Janeiro	84	12	96
2018 Dezembro	37	11	48
2018 Novembro	95	15	110
2018 Outubro	212	17	229
2018 Setembro	66	20	86
2018 Agosto	58	39	97
2018 Julho	36	8	44
2018 Junho	61	13	74
2018 Maio	82	25	107
2018 Abril	51	9	60
2018 Mar�o	180	8	188
2018 Fevereiro	65	7	72
2018 Janeiro	67	5	72
2017 Dezembro	42	9	51
2017 Novembro	51	14	65
2017 Outubro	55	13	68
2017 Setembro	45	16	61
2017 Agosto	47	11	58
2017 Julho	23	12	35
2017 Junho	39	32	71
2017 Maio	64	11	75
2017 Abril	26	2	28
2017 Mar�o	43	71	114
2017 Fevereiro	60	6	66
2017 Janeiro	71	7	78
2016 Dezembro	38	13	51
2016 Novembro	31	9	40
2016 Outubro	26	11	37
2016 Setembro	37	8	45
2016 Agosto	24	6	30
2016 Julho	19	4	23
2016 Junho	3	0	3
2016 Maio	2	5	7
2016 Abril	24	1	25
2016 Mar�o	47	6	53
2016 Fevereiro	67	11	78
2016 Janeiro	43	11	54
2015 Dezembro	49	7	56
2015 Novembro	41	7	48
2015 Outubro	44	12	56
2015 Setembro	59	10	69
2015 Agosto	62	9	71
2015 Julho	43	8	51
2015 Junho	45	5	50
2015 Maio	51	7	58
2015 Abril	33	18	51
2015 Mar�o	34	3	37
2015 Fevereiro	22	4	26
2015 Janeiro	21	12	33
2014 Dezembro	42	11	53
2014 Novembro	54	13	67
2014 Outubro	44	18	62
2014 Setembro	59	23	82
2014 Agosto	77	57	134
2014 Julho	81	43	124

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