A 72-year-old male without relevant past medical history presented to the emergency room with severe oppressive chest pain two hours after onset. The electrocardiogram showed ST-segment elevation in the inferior leads with ST-segment depression in I, aVL, V2 and V3 (Figure 1, panel A) and ST elevation in posterior leads suggesting posteroinferior acute ST elevation myocardial infarction (STEMI). An emergent coronary angiography was performed with multiple and unsuccessful attempts at right coronary artery (RCA) catheterization. When left coronary artery catheterization was performed, circumflex artery (Cx) occlusion was identified (Figure 1, panel B) and, after primary coronary intervention (PCI) with a drug-eluted stent (XienceTM 2.75/28 mm post-dilated to 3.25 mm), a superdominant left Cx was observed (Figure 1, panel C) in a patient with no RCA. The absence of RCA was further confirmed by computed tomography coronary angiography (Figure 1, panels D and E).

Figure 1.

Panel A: ECG with ST-segment elevation in the inferior leads. Panel B: Circunflex (Cx) artery occlusion (arrow) during coronary angiography. Panel C shows a superdominant Cx artery after angioplasty. Panels D and E are CT scan images showing a superdominant Cx artery and absence of right coronary artery (coronary agenesis).

Congenital agenesis of RCA is a rare coronary anomaly (under forty published cases)1 and its diagnosis during STEMI is even rarer. The cause of this is unclear, with some authors suggesting the hypothesis of congenital occlusion of the RCA during the embryonic period.2 As a teaching point, we should consider angiography of the non-culprit artery first, as it can reveal major coronary anomalies, such as superdominant vessels, and thus save time by preventing unnecessary attempts at catheterization of a non-dominant or inexistent vessel.