Case report
Acute coronay syndrome in a patient with severe hemophilia A: Dificult decisions
Síndrome coronária aguda em doente com hemofilia A grave: decisões difíceis
Read
8537
Timeswas read the article
2048
Total PDF
6489
Total HTML
Share statistics
array:25 [ "pii" => "S2174204921002841" "issn" => "21742049" "doi" => "10.1016/j.repce.2021.10.002" "estado" => "S300" "fechaPublicacion" => "2021-12-01" "aid" => "1803" "copyright" => "Sociedade Portuguesa de Cardiologia" "copyrightAnyo" => "2021" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "crp" "cita" => "Rev Port Cardiol. 2021;40:985.e1-985.e5" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "Traduccion" => array:1 [ "pt" => array:20 [ "pii" => "S0870255121003590" "issn" => "08702551" "doi" => "10.1016/j.repc.2018.09.017" "estado" => "S300" "fechaPublicacion" => "2021-12-01" "aid" => "1803" "copyright" => "Sociedade Portuguesa de Cardiologia" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "crp" "cita" => "Rev Port Cardiol. 2021;40:985.e1-985.e5" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "pt" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Caso Clínico</span>" "titulo" => "Síndrome coronária aguda em doente com hemofilia A grave: decisões difíceis" "tienePdf" => "pt" "tieneTextoCompleto" => "pt" "tieneResumen" => array:2 [ 0 => "pt" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "985.e1" "paginaFinal" => "985.e5" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Acute coronay syndrome in a patient with severe hemophilia A: Dificult decisions" ] ] "contieneResumen" => array:2 [ "pt" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "pt" => true ] "contienePdf" => array:1 [ "pt" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 853 "Ancho" => 2167 "Tamanyo" => 76576 ] ] "descripcion" => array:1 [ "pt" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Heredograma do doente.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Inês Aguiar Ricardo, João Agostinho, Artur Pereira, Fátima Rodrigues, Dulce Brito, Fausto J. Pinto, Cristina Catarino, Mónica Mendes Pedro" "autores" => array:8 [ 0 => array:2 [ "nombre" => "Inês" "apellidos" => "Aguiar Ricardo" ] 1 => array:2 [ "nombre" => "João" "apellidos" => "Agostinho" ] 2 => array:2 [ "nombre" => "Artur" "apellidos" => "Pereira" ] 3 => array:2 [ "nombre" => "Fátima" "apellidos" => "Rodrigues" ] 4 => array:2 [ "nombre" => "Dulce" "apellidos" => "Brito" ] 5 => array:2 [ "nombre" => "Fausto J." "apellidos" => "Pinto" ] 6 => array:2 [ "nombre" => "Cristina" "apellidos" => "Catarino" ] 7 => array:2 [ "nombre" => "Mónica" "apellidos" => "Mendes Pedro" ] ] ] ] ] "idiomaDefecto" => "pt" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2174204921002841" "doi" => "10.1016/j.repce.2021.10.002" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204921002841?idApp=UINPBA00004E" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255121003590?idApp=UINPBA00004E" "url" => "/08702551/0000004000000012/v1_202112081446/S0870255121003590/v1_202112081446/pt/main.assets" ] ] "itemSiguiente" => array:20 [ "pii" => "S2174204921003718" "issn" => "21742049" "doi" => "10.1016/j.repce.2021.11.018" "estado" => "S300" "fechaPublicacion" => "2021-12-01" "aid" => "1804" "copyright" => "Sociedade Portuguesa de Cardiologia" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "sco" "cita" => "Rev Port Cardiol. 2021;40:987-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Image in Cardiology</span>" "titulo" => "Sinus Node Syndrome in a critical COVID-19 patient" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "987" "paginaFinal" => "988" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Doença do nódulo sinusal num doente crítico com COVID-19" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1125 "Ancho" => 1500 "Tamanyo" => 304205 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A) Electrocardiogram showing sinus bradycardia and (B) sinus arrest with a pause >6 seconds. (C and D) Chest x-ray showing bilateral pulmonary infiltrates predominantly peripheral, before and after pacemaker implantation.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Juliana Elices-Teja, Álvaro Bueno-Sacristán, Olga Durán-Bobin, Ana María Ferreiro-González, Carlos Gonzalez-Juanatey" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Juliana" "apellidos" => "Elices-Teja" ] 1 => array:2 [ "nombre" => "Álvaro" "apellidos" => "Bueno-Sacristán" ] 2 => array:2 [ "nombre" => "Olga" "apellidos" => "Durán-Bobin" ] 3 => array:2 [ "nombre" => "Ana María" "apellidos" => "Ferreiro-González" ] 4 => array:2 [ "nombre" => "Carlos" "apellidos" => "Gonzalez-Juanatey" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0870255121003607" "doi" => "10.1016/j.repc.2020.09.015" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255121003607?idApp=UINPBA00004E" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204921003718?idApp=UINPBA00004E" "url" => "/21742049/0000004000000012/v1_202112160943/S2174204921003718/v1_202112160943/en/main.assets" ] "itemAnterior" => array:20 [ "pii" => "S2174204921003706" "issn" => "21742049" "doi" => "10.1016/j.repce.2021.11.017" "estado" => "S300" "fechaPublicacion" => "2021-12-01" "aid" => "1801" "copyright" => "Sociedade Portuguesa de Cardiologia" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "pgl" "cita" => "Rev Port Cardiol. 2021;40:975-83" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Guidelines</span>" "titulo" => "Optimization of heart failure with reduced ejection fraction prognosis-modifying drugs: A 2021 heart failure expert consensus paper" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "pt" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "975" "paginaFinal" => "983" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Otimização do tratamento da insuficiência cardíaca com fração de ejeção reduzida com fármacos modificadores de prognóstico: um documento de consenso de 2021 por especialistas em insuficiência cardíaca" ] ] "contieneResumen" => array:2 [ "en" => true "pt" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 915 "Ancho" => 2500 "Tamanyo" => 129268 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Treatment algorithm for heart failure with reduced ejection fraction diabetic patients: A two-step sequence for the initiation of the four foundational drugs.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "José Silva-Cardoso, Cândida Fonseca, Fátima Franco, João Morais, Jorge Ferreira, Dulce Brito" "autores" => array:6 [ 0 => array:2 [ "nombre" => "José" "apellidos" => "Silva-Cardoso" ] 1 => array:2 [ "nombre" => "Cândida" "apellidos" => "Fonseca" ] 2 => array:2 [ "nombre" => "Fátima" "apellidos" => "Franco" ] 3 => array:2 [ "nombre" => "João" "apellidos" => "Morais" ] 4 => array:2 [ "nombre" => "Jorge" "apellidos" => "Ferreira" ] 5 => array:2 [ "nombre" => "Dulce" "apellidos" => "Brito" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0870255121003553" "doi" => "10.1016/j.repc.2021.07.009" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255121003553?idApp=UINPBA00004E" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204921003706?idApp=UINPBA00004E" "url" => "/21742049/0000004000000012/v1_202112160943/S2174204921003706/v1_202112160943/en/main.assets" ] "en" => array:20 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>" "titulo" => "Acute coronay syndrome in a patient with severe hemophilia A: Dificult decisions" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "985.e1" "paginaFinal" => "985.e5" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Inês Aguiar-Ricardo, João Agostinho, Artur Pereira, Fátima Rodrigues, Dulce Brito, Fausto J. Pinto, Cristina Catarino, Mónica Mendes Pedro" "autores" => array:8 [ 0 => array:4 [ "nombre" => "Inês" "apellidos" => "Aguiar-Ricardo" "email" => array:1 [ 0 => "ines.a.ricardo@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "João" "apellidos" => "Agostinho" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "Artur" "apellidos" => "Pereira" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "Fátima" "apellidos" => "Rodrigues" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "Dulce" "apellidos" => "Brito" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 5 => array:3 [ "nombre" => "Fausto J." "apellidos" => "Pinto" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 6 => array:3 [ "nombre" => "Cristina" "apellidos" => "Catarino" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 7 => array:3 [ "nombre" => "Mónica" "apellidos" => "Mendes Pedro" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Cardiology Department, Santa Maria University Hospital CHULN, CAML, CCUL, Lisbon School of Medicine, Universidade de Lisboa, Portugal" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Immunohemotherapy Department, Santa Maria University Hospital CHULN, CAML, CCUL, Lisbon School of Medicine, Universidade de Lisboa, Portugal" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Síndrome coronária aguda em doente com hemofilia A grave: decisões difíceis" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 784 "Ancho" => 800 "Tamanyo" => 100618 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Bilateral arthropathy of the knees.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Hemophilia A is a severe inherited coagulation disorder characterized by a deficiency of factor VIII (FVIII) coagulation activity and is associated with significant bleeding risk. This disease is characterized by alterations in the FVIII gene located on the long arm of the X chromosome and therefore affects almost exclusively males, with females usually only carrying the mutation.</p><p id="par0010" class="elsevierStylePara elsevierViewall">The severity of the disease depends on the level of FVIII and is classified as mild (FVIII >5%), moderate (FVIII 2-5%) and severe (FVIII <1%).<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The clinical picture of hemophilia is characterized by spontaneous or trauma-related hemorrhagic episodes, in the most part, joint (hemarthroses) and muscle hemorrhages. Repeated joint hemorrhages lead to progressive functional disability (hemophilic arthropathy), while other types of hemorrhage, such as central nervous system hemorrhages, can be fatal if not correctly treated. Surgical procedures are a risk in people with this disease, so any invasive procedures require adequate therapy and monitoring by a multidisciplinary team.</p><p id="par0020" class="elsevierStylePara elsevierViewall">In recent decades, there have been remarkable advances in hemophilia therapeutic options with increasing availability of factor concentrates, which are effective in the prevention and treatment of hemorrhagic episodes. These therapies have increased the average life expectancy of these patients from <30 years to about 70 years,<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> similar to that of the general population. However, treatment with the missing factor is also responsible for the most serious iatrogenic complication in these patients: the development of antibodies (inhibitors) against the missing factor. These antibodies, which develop in 30-40% of patients and, in most cases, within the first 20 days of exposure to therapy,<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> render therapy ineffective and severely compromise the therapeutic options and prognosis of these patients. The etiopathogenesis of inhibitor development seems to be multifactorial and depends on genetic and non-genetic factors.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> In the case of the latter, treatment intensity (defined as more than five days of treatment) is a well-established risk factor.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">In relation to the risk of thrombotic events, and contrary to what one might think, this remains despite the high hemorrhagic risk of these patients. Regardless of any protective effect that may be associated with the coagulation defect, the same factors that contribute to cardiovascular disease in the general population also have an impact on the hemophilia population. Individuals with hemophilia are particularly vulnerable to the development of metabolic syndrome, given the prevalence of obesity and inactivity resulting from hemophilic arthropathy.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> Hypertension also seems to be more frequent in hemophiliac patients than in the general population,<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> and although the mechanism is not yet fully understood, it is thought to be associated with microangiopathy of the liver.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Cardiovascular diseases are a major cause of morbidity and mortality worldwide. In recent years, due to the already mentioned increase in the life expectancy of hemophilia patients and the inherent presence of comorbidities associated with aging, there has been an increase in cardiovascular events in this population.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The treatment of acute coronary syndrome (ACS) in hemophiliac patients is a real challenge because, if on the one hand anticoagulation and antiplatelet increase the hemorrhagic risk (already high in these patients), on the other hand, correction of anticoagulation with the factor in deficit increases the risk of thrombosis.</p><p id="par0040" class="elsevierStylePara elsevierViewall">We describe the clinical case of ACS in a patient with severe hemophilia A, who underwent invasive procedures, without hemorrhagic or thrombotic complications, thus demonstrating the importance of a multidisciplinary approach in these situations.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Clinical case</span><p id="par0045" class="elsevierStylePara elsevierViewall">We describe the case of a 48-year-old man from Cape Verde, evacuated from his country of origin due to unstable angina. The patient had a known personal history of type 2 diabetes and severe hemophilia A. In addition to oral antidiabetic therapy, he was taking acetylsalicylic acid (ASA) 100 mg/day. Despite mentioning numerous episodes of hemarthrosis and presenting chronic joint alterations, he had never been treated for this disease. Family history included three nephews and a brother (who died of intracranial hemorrhage at the age of 15) diagnosed with severe hemophilia A (<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0050" class="elsevierStylePara elsevierViewall">The patient complained of stress angina with an evolution of approximately six months, progressively worsening and evolving to pain at rest (Class IV of the Canadian Cardiology Society. The patient had been started on ASA 100mg/day in Cape Verde and at the time of assessment, he was asymptomatic. The objective examination showed no other alterations apart from evidence of bilateral arthropathy at the knee (<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>). Laboratory analyses, in particular, prothrombin time and platelet count, were normal and activated partial thromboplastin time >100 seconds, FVIII <1% and FVIII inhibitors were negative. Myocardial necrosis markers were negative, and there were no other laboratory test abnormalities except for hemoglobin of 9.1g/dL. The electrocardiogram showed sinus rhythm, Q wave in aVL, with no other repolarization changes; the echocardiogram was normal.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">The clinical situation was discussed at a multidisciplinary meeting (a hematologist specializing in hemophilia, a clinical cardiologist and an interventional cardiologist) and it was decided to admit him to the cardiology department to undergo a coronary angiography.</p><p id="par0060" class="elsevierStylePara elsevierViewall">Prior to this invasive examination, 50 IU/kg of FVIII was administered and the pre-catheterization FVIII value was 66%. Prior to coronary angiography, a platelet pool transfusion was also performed based on the platelet aggregation study performed by rotational thromboelastometry (ROTEM platelet system), which indicated marked platelet inhibition.</p><p id="par0065" class="elsevierStylePara elsevierViewall">Coronary angiography revealed significant disease in the anterior descending artery - 85% ostial stenosis and 70% proximal stenosis up to the emergence of the first diagonal. No significant lesions were observed in the remaining vessels via angiography. Pre-dilatation with a balloon was performed on the proximal and ostial lesion of the anterior descending artery, and a 3.5×28mm antiproliferative stent was then implanted, with good final angiographic results (<a class="elsevierStyleCrossRef" href="#fig0015">Figure 3</a>).</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">A loading dose of 600 mg of clopidogrel was administered during the procedure, and afterwards dual antiplatelet therapy was maintained with clopidogrel 75mg and ASA 100 mg. In the 72 hours following the coronary angiography, FVIII therapy was maintained at intervals of eight and 12 hours and FVIII levels varied between 38 and 46%.</p><p id="par0075" class="elsevierStylePara elsevierViewall">There were no hemorrhagic complications and hospitalization was uneventful. The patient was discharged on ASA and clopidogrel, with the indication to maintain dual therapy for three months, later interrupting clopidogrel and maintaining ASA indefinitely.</p><p id="par0080" class="elsevierStylePara elsevierViewall">In the first 10 days, he underwent daily replacement therapy, maintaining FVIII levels at around 10%. Subsequently, according to the pharmacokinetics results and the decision to maintain FVIII levels between 3 and 5%, prophylactic therapy was started on alternate days (40 IU/kg). In this patient, and despite intensive treatment, testing for inhibitors was always negative.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0085" class="elsevierStylePara elsevierViewall">Addressing acute coronary events in hemophilic patients, as demonstrated in the present case, is a real challenge. The bleeding risk, already high in these patients, is aggravated not only by the hypocoagulation that is necessary during angioplasty, but also by the anti-platelet therapy that is indispensable in the treatment of ACS and in the prevention of stent thrombosis. On the other hand, there are no recommendations regarding the most adequate and safe factor levels in this type of intervention and during antiplatelet therapy, which require a multidisciplinary approach and strict monitoring.</p><p id="par0090" class="elsevierStylePara elsevierViewall">According to the European Hemophilia Association, adequate correction with FVIII concentrate is recommended before percutaneous coronary intervention (PCI) and in the subsequent 48h, without specifying the minimum ideal target value. Thus, little is defined beyond the guidelines proposed by an expert consensus published in 2013,<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> where it is suggested that PCI be performed as early as possible, under adequate protection with FVIII, ideally for FVIII values >80% and that in the first 24h after PCI the levels should be ∼50%. This document also proposes FVIII levels between 5 and 15% during dual antiplatelet therapy and >1% when on monotherapy.</p><p id="par0095" class="elsevierStylePara elsevierViewall">In the case of this patient, the pre-PCI values were not achieved, but despite this, there were no hemorrhagic complications, and the levels of FVIII >60% proved to be sufficient and safe. The decision to maintain daily therapy for only 10 days, and subsequently on alternate days, was due to various reasons. If, on the one hand, despite being an adult, venous accesses proved to be an unexpected difficulty, the risk of developing inhibitors was a complication to be considered, in this patient. Experience related to antiplatelet and anticoagulation in hemophilia, apart from being scarce, concerns patients treated many years ago with factor concentrates and in whom the risk of developing inhibitors is practically zero.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> In this patient's case, the risk of the appearance of inhibitors was high, as the first exposure to exogenous FVIII was in a period of intensive treatment, where the risk of antibody development is at a maximum.<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5,11</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">Despite the absence of recommendations to carry out a platelet aggregation test in these situations, given the high risk of hemorrhage and the fact that the patient was already previously medicated with antiplatelets, we decided to perform a thromboelastometry, which showed significant platelet inhibition and led to the choice to give treatment with platelet support.</p><p id="par0105" class="elsevierStylePara elsevierViewall">During catheterization, 10500 IU of unfractionated heparin was administered. Although there are some reports in the literature in which bivalirudin was preferred in hemophilia patients,<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">12,13</span></a> since it is associated with a lower rate of bleeding complications, unfractionated heparin is still the preferred anticoagulant in view of its relatively short half-life and the possibility of reversibility, if applicable.</p><p id="par0110" class="elsevierStylePara elsevierViewall">Dual antiplatelet therapy is recommended after angioplasty to prevent stent thrombosis. Regarding the choice of antiplatelet drugs, ticagrelor and prasugrel have shown superiority in reducing ischemic complications after ACS when compared to clopidogrel, but they are also associated with higher rates of spontaneous bleeding.<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">14,15</span></a> These drugs are strongly recommended in European Cardiology Guidelines for the treatment of ACS in the general population. However, there are no studies in hemophilia patients and therefore they should not be used in these patients. In this case we opted for dual therapy with ASA and clopidogrel for three months, after which the patient remained on ASA alone.</p><p id="par0115" class="elsevierStylePara elsevierViewall">In the past, bare metal stents (BMS) required dual antiplatelet therapy for four to six weeks while first generation drug eluting stents (DES) required dual antiplatelet therapy for six to 12 months. Thus, in patients at a high bleeding risk, BMS were always preferred.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> However, currently, for new generation DES, the duration of dual antiplatelet therapy is similar to that required for BMS. In the RESET<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> and OPTIMIZE<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> studies, the use of antiplatelet therapy for three months was shown not to be inferior in terms of safety during a follow-up period of one year.</p><p id="par0120" class="elsevierStylePara elsevierViewall">In the present case the use of DES was chosen, despite there being few existing reports of its use in hemophiliac patients, after setting minimum levels for FVIII safety. No bleeding complications were observed, probably due to strict laboratory monitoring and multidisciplinary surveillance.</p><p id="par0125" class="elsevierStylePara elsevierViewall">According to European recommendations, in patients with high bleeding risk, the duration of dual antiplatelet therapy should be kept to a minimum.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> However, there is no evidence regarding patients with bleeding dyscrasias, as these are excluded from most studies. The expert consensus published by the ADVANCE Working Group suggests maintaining dual antiplatelet therapy for one month, but only mentions the use of BMS.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> The use of dual antiplatelet therapy for one month with DES has also been assessed, but only with specific stents: Endeavor Sprint and BioFreedom.<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">20,21</span></a> Although these studies included patients with ACS, European guidelines consider that dual therapy for one month should be restricted to patients with stable coronary disease and high bleeding risk (class IIb).<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> Thus, in this case, as it was ACS, there was significant risk of stent thrombosis associated with a critical lesion of the descending artery. In addition to the unavailability of the aforementioned stents, and since the patient would maintain strict follow-up in the immunohemotherapy day hospital, we decided to maintain dual antiplatelet therapy for three months.</p><p id="par0130" class="elsevierStylePara elsevierViewall">As for adjuvant therapy, besides the usual medication to control risk factors and prognostic modifying drugs, the addition of a proton pump inhibitor is also recommended in these patients.<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9,19</span></a></p><p id="par0135" class="elsevierStylePara elsevierViewall">Although most angioplasty surgery described in hemophilia patients has been safely performed using a femoral approach, in this patient the coronary angiography was performed using a right radial approach. This is the recommended access, if technically possible, as the vessel is smaller-caliber and peripheral, allowing easier hemostasis and minimizing bleeding complications, without compromising the success of the procedure.</p><p id="par0140" class="elsevierStylePara elsevierViewall">In conclusion, the authors describe the clinical case of a patient with unstable angina and diagnosis of severe hemophilia A, who underwent a successful PCI of the anterior descending artery, under therapy with FVIII, having taken conventional medical therapy with dual antiplatelet therapy without any hemorrhagic complications.</p><p id="par0145" class="elsevierStylePara elsevierViewall">Although the recommendations published by the European Society of Cardiology are based on studies that excluded patients with bleeding dyscrasias, this case is an example that hemophilia patients, if adequately assessed, treated and monitored, and despite the high bleeding risk, can have access to the same therapeutic interventions as non-hemophilia patients and according to the state of the art for ACS.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conflicts of interest</span><p id="par0150" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:9 [ 0 => array:3 [ "identificador" => "xres1629633" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1454440" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres1629634" "titulo" => "Resumo" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0010" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec1454439" "titulo" => "Palavras-chave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Clinical case" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Discussion" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Conflicts of interest" ] 8 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2018-04-18" "fechaAceptado" => "2018-09-10" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1454440" "palabras" => array:5 [ 0 => "Acute coronary syndrome" 1 => "Unstable angina" 2 => "Hemophilia A" 3 => "Factor VIII" 4 => "Hemorrhagic risk" ] ] ] "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec1454439" "palabras" => array:5 [ 0 => "Síndrome coronária aguda" 1 => "Angina instável" 2 => "Hemofilia A" 3 => "Factor VIII" 4 => "Risco hemorrágico" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Hemophilia A is an inherited coagulation disease characterized by factor VIII (FVIII) deficiency and is associated with high hemorrhagic risk, especially in its severe forms. As the average life expectancy of patients with hemophilia has increased, so has the prevalence of acute coronary events. There is however limited experience in dealing with them. The strategy of acting on acute coronary events in patients with hemophilia, as demonstrated in the present case, is a real challenge, not only due to the need for antiplatelet therapy (which is essential in the prevention of stent thrombosis, but increases hemorrhagic risk), but also due to the lack of specific recommendations related to the most adequate and safe replacement therapy in these situations. The authors describe the case of a 48-year-old man with unstable angina and a previous diagnosis of severe hemophilia A who underwent percutaneous coronary intervention under FVIII therapy without hemorrhagic complications.</p></span>" ] "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">A hemofilia A é uma doença hereditária da coagulação caracterizada por uma deficiência de fator VIII (FVIII) e que, principalmente nas suas formas graves, está associada a um risco hemorrágico elevado. Com o aumento da esperança média de vida destes doentes, a prevalência de eventos coronários agudos tem aumentado, mas a experiência na abordagem destes permanece escassa. A estratégia de atuação nos eventos coronários agudos em doentes hemofílicos, como demonstrado no presente caso, representa um verdadeiro desafio, não só pela necessidade de terapêutica anti‐agregante plaquetária (a qual, sendo indispensável para prevenção de trombose de stent, aumenta o risco hemorrágico), como também pela inexistência de recomendações específicas relacionadas com a terapêutica substitutiva mais adequada e segura nestas situações. Os autores descrevem o caso de um homem de 48 anos, com angina instável e diagnóstico prévio de hemofilia A grave, submetido a intervenção coronária percutânea sob terapêutica com FVIII sem complicações hemorrágicas.</p></span>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Aguiar-Ricardo I, Agostinho J, Pereira A, Rodrigues F, Brito D, Pinto FJ, et al. Síndrome coronária aguda em doente com hemofilia A grave: decisões difíceis. Rev Port Cardiol. 2021;40:985–989.</p>" ] ] "multimedia" => array:3 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 853 "Ancho" => 2167 "Tamanyo" => 84471 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Heredogram of the patient.</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 784 "Ancho" => 800 "Tamanyo" => 100618 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Bilateral arthropathy of the knees.</p>" ] ] 2 => array:8 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 586 "Ancho" => 1250 "Tamanyo" => 64226 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A critical lesion of the ostial and proximal anterior descending artery. B Angiography of the anterior descending artery after implantation of a 3.5×28mm stent.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:21 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Definitions in hemophilia. Recommendation of the scientific subcommittee on factor VIII and factor IX of the scientific and standardization committee of the International Society on Thrombosis and Haemostasis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "G.C. White 2nd" 1 => "F. Rosendaal" 2 => "L.M. Aledort" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thromb Haemost" "fecha" => "2001" "volumen" => "85" "paginaInicial" => "560" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11307831" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0009739X13000973" "estado" => "S300" "issn" => "0009739X" ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mortality rates, life expectancy, and causes of death in people with hemophilia A or B in the United Kingdom who were not infected with HIV" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "S.C. Darby" 1 => "S.W. Kan" 2 => "R.J. Spooner" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1182/blood-2006-10-050435" "Revista" => array:6 [ "tituloSerie" => "Blood" "fecha" => "2007" "volumen" => "110" "paginaInicial" => "815" "paginaFinal" => "825" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17446349" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The epidemiology of inhibitors in haemophilia A: a systematic review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Wight" 1 => "S. Paisley" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1046/j.1365-2516.2003.00780.x" "Revista" => array:6 [ "tituloSerie" => "Haemophilia" "fecha" => "2003" "volumen" => "9" "paginaInicial" => "418" "paginaFinal" => "435" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12828678" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Understanding inhibitor development in haemophilia A: towards clinical prediction and prevention strategies" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "A. Coppola" 1 => "C. Santoro" 2 => "A. Tagliaferri" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2516.2010.02254.x" "Revista" => array:7 [ "tituloSerie" => "Haemophilia" "fecha" => "2010" "volumen" => "16" "numero" => "Suppl 1" "paginaInicial" => "13" "paginaFinal" => "19" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20586796" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intensity of factor VIII treatment and inhibitor development in children with severe hemophilia A: the RODIN study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "S.C. Gouw" 1 => "H.M. van den Berg" 2 => "K. Fischer" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Blood" "fecha" => "2013" "volumen" => "121" "paginaInicial" => "4046" "paginaFinal" => "4055" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Emerging clinical concerns in the ageing haemophilia patient" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "B.A. Konkle" 1 => "C. Kessler" 2 => "L. Aledort" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2516.2009.02066.x" "Revista" => array:7 [ "tituloSerie" => "Haemophilia" "fecha" => "2009" "volumen" => "15" "paginaInicial" => "1197" "paginaFinal" => "1209" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19686466" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S2213858720301571" "estado" => "S300" "issn" => "22138587" ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A cross-sectional study of comorbidities and hypertension in patients with hemophilia A and B in Europe: Interim results from the H3 study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "P. Holme" 1 => "C. Combescure" 2 => "E. Berntorp" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Haemophilia" "fecha" => "2014" "volumen" => "20" "paginaInicial" => "63" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Renal disease among males with haemophilia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R. Kulkarni" 1 => "J.M. Soucie" 2 => "B. Evatt" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1046/j.1351-8216.2003.00821.x" "Revista" => array:7 [ "tituloSerie" => "Haemophilia" "fecha" => "2003" "volumen" => "9" "paginaInicial" => "703" "paginaFinal" => "710" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14750936" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0009739X15000408" "estado" => "S300" "issn" => "0009739X" ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Applicability of the European Society of Cardiology guidelines on management of acute coronary syndromes to people with haemophilia - an assessment by the ADVANCE Working Group" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "P. Staritz" 1 => "P. de Moerloose" 2 => "R. Schutgens" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/hae.12189" "Revista" => array:6 [ "tituloSerie" => "Haemophilia" "fecha" => "2013" "volumen" => "19" "paginaInicial" => "833" "paginaFinal" => "840" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23710576" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Incidence of factor VIII inhibitors throughout life in severe hemophilia A in the United Kingdom" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "C.R.M. Hay" 1 => "B. Palmer" 2 => "E. Chalmers" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1182/blood-2010-09-308668" "Revista" => array:6 [ "tituloSerie" => "Blood" "fecha" => "2011" "volumen" => "117" "paginaInicial" => "6367" "paginaFinal" => "6370" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21471523" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment-related risk factors of inhibitor development in previously untreated patients with hemophilia A: the CANAL cohort study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S.C. Gouw" 1 => "J.G. van der Bom" 2 => "H. Marijke van den Berg" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1182/blood-2006-11-056291" "Revista" => array:6 [ "tituloSerie" => "Blood" "fecha" => "2007" "volumen" => "109" "paginaInicial" => "4648" "paginaFinal" => "4654" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17289808" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Successful multi-vessel percutaneous coronary intervention with bivalirudin in a patient with severe hemophilia A: a case report and review of literature" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "U.K. Arora" 1 => "M. Dhir" 2 => "G. Cintron" ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Invasive Cardiol [Internet]" "fecha" => "2004" "volumen" => "16" "paginaInicial" => "330" "paginaFinal" => "332" "itemHostRev" => array:3 [ "pii" => "S002577531300523X" "estado" => "S300" "issn" => "00257753" ] ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "http://www.ncbi.nlm.nih.gov/pubmed/15156005" ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Successful percutaneous coronary intervention in a patient with severe haemophilia A using bivalirudin as the sole procedural anticoagulant" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M.A. Krolick" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2516.2005.01103.x" "Revista" => array:6 [ "tituloSerie" => "Haemophilia" "fecha" => "2005" "volumen" => "11" "paginaInicial" => "415" "paginaFinal" => "417" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16011598" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prasugrel versus Clopidogrel in Patients with Acute Coronary Syndromes" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "S.D. Wiviott" 1 => "E. Braunwald" 2 => "C.H. McCabe" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa0706482" "Revista" => array:5 [ "tituloSerie" => "N Engl J Med [Internet]" "fecha" => "2007" "volumen" => "357" "paginaInicial" => "2001" "paginaFinal" => "2015" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ticagrelor versus Clopidogrel in Patients with Acute Coronary Syndromes" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "L. Wallentin" 1 => "R.C. Becker" 2 => "A. Budaj" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa0904327" "Revista" => array:5 [ "tituloSerie" => "N Engl J Med [Internet]" "fecha" => "2009" "volumen" => "361" "paginaInicial" => "1045" "paginaFinal" => "1057" ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "2014 ESC/EACTS Guidelines on myocardial revascularization: The Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)Developed with the special contribution o" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "S. Windecker" 1 => "P. Kolh" 2 => "F. Alfonso" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/eurheartj/ehu278" "Revista" => array:6 [ "tituloSerie" => "Eur Heart J" "fecha" => "2014" "volumen" => "35" "paginaInicial" => "2541" "paginaFinal" => "2619" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25173339" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Three vs twelve months of dual antiplatelet therapy after zotarolimus-eluting stents: the OPTIMIZE randomized trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "F. Feres" 1 => "R.A. Costa" 2 => "A. Abizaid" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/jama.2013.282183" "Revista" => array:6 [ "tituloSerie" => "JAMA" "fecha" => "2013" "volumen" => "310" "paginaInicial" => "2510" "paginaFinal" => "2522" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24177257" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A new strategy for discontinuation of dual antiplatelet therapy: the RESET Trial (REal Safety and Efficacy of 3-month dual antiplatelet Therapy following Endeavor zotarolimus-eluting stent implantation)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "B.-K. Kim" 1 => "M.-K. Hong" 2 => "D.-H. Shin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jacc.2012.06.043" "Revista" => array:6 [ "tituloSerie" => "J Am Coll Cardiol" "fecha" => "2012" "volumen" => "60" "paginaInicial" => "1340" "paginaFinal" => "1348" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22999717" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTSThe Task Force for dual antiplatelet therapy in coronary artery disease of the European Society of Cardiology (ESC) and of the European As" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M. Valgimigli" 1 => "H. Bueno" 2 => "R.A. Byrne" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/eurheartj/ehx419" "Revista" => array:5 [ "tituloSerie" => "Eur Heart J [Internet]" "fecha" => "2018" "volumen" => "39" "paginaInicial" => "213" "paginaFinal" => "260" ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Polymer-free Drug-Coated Coronary Stents in Patients at High Bleeding Risk" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "P. Urban" 1 => "I.T. Meredith" 2 => "A. Abizaid" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa1503943" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2015" "volumen" => "373" "paginaInicial" => "2038" "paginaFinal" => "2047" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26466021" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Zotarolimus-eluting versus bare-metal stents in uncertain drug-eluting stent candidates" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Valgimigli" 1 => "A. Patialiakas" 2 => "A. Thury" 3 => "E. McFadden" 4 => "S. Colangelo" 5 => "G. Campo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jacc.2014.11.053" "Revista" => array:6 [ "tituloSerie" => "J Am Coll Cardiol" "fecha" => "2015" "volumen" => "65" "paginaInicial" => "805" "paginaFinal" => "815" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25720624" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/21742049/0000004000000012/v1_202112160943/S2174204921002841/v1_202112160943/en/main.assets" "Apartado" => array:4 [ "identificador" => "9914" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Case report" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/21742049/0000004000000012/v1_202112160943/S2174204921002841/v1_202112160943/en/main.pdf?idApp=UINPBA00004E&text.app=https://www.revportcardiol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204921002841?idApp=UINPBA00004E" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 October | 282 | 45 | 327 |
| 2024 September | 302 | 42 | 344 |
| 2024 August | 462 | 79 | 541 |
| 2024 July | 299 | 40 | 339 |
| 2024 June | 197 | 46 | 243 |
| 2024 May | 249 | 50 | 299 |
| 2024 April | 291 | 46 | 337 |
| 2024 March | 306 | 35 | 341 |
| 2024 February | 270 | 40 | 310 |
| 2024 January | 289 | 49 | 338 |
| 2023 December | 120 | 53 | 173 |
| 2023 November | 241 | 98 | 339 |
| 2023 October | 230 | 58 | 288 |
| 2023 September | 165 | 45 | 210 |
| 2023 August | 177 | 39 | 216 |
| 2023 July | 133 | 32 | 165 |
| 2023 June | 122 | 29 | 151 |
| 2023 May | 157 | 118 | 275 |
| 2023 April | 117 | 44 | 161 |
| 2023 March | 166 | 62 | 228 |
| 2023 February | 107 | 50 | 157 |
| 2023 January | 97 | 49 | 146 |
| 2022 December | 112 | 58 | 170 |
| 2022 November | 97 | 67 | 164 |
| 2022 October | 112 | 51 | 163 |
| 2022 September | 101 | 61 | 162 |
| 2022 August | 121 | 50 | 171 |
| 2022 July | 226 | 102 | 328 |
| 2022 June | 161 | 64 | 225 |
| 2022 May | 109 | 73 | 182 |
| 2022 April | 105 | 66 | 171 |
| 2022 March | 117 | 71 | 188 |
| 2022 February | 85 | 61 | 146 |
| 2022 January | 157 | 68 | 225 |
| 2021 December | 146 | 69 | 215 |
| 2021 November | 61 | 38 | 99 |
Show all
