TY - JOUR T1 - The predictive value of epicardial fat volume for clinical severity of COVID-19 JO - Revista Portuguesa de Cardiologia T2 - AU - Erdöl,Mehmet Akif AU - Civelek Eser,Fatma AU - Aslan,Abdullah Nabi AU - Erdoğan,Mehmet AU - Altunsoy Aypak,Adalet AU - Beşler,Muhammed Said AU - Kaya Kalem,Ayşe AU - Ertem,Ahmet Göktuğ AU - Güner,Hatice Rahmet SN - 08702551 M3 - 10.1016/j.repc.2021.05.016 DO - 10.1016/j.repc.2021.05.016 UR - https://www.revportcardiol.org/pt-the-predictive-value-epicardial-fat-articulo-S0870255122001573 AB - IntroductionEpicardial adipose tissue serves as a source of inflammatory cytokines and mediators. Cytokine storm is an important cause of morbidity and mortality in coronavirus disease 2019 (COVID-19). ObjectivesTo investigate the association between epicardial fat volume (EFV), inflammatory biomarkers and clinical severity of COVID-19. MethodsThis retrospective study included 101 patients who were infected with COVID-19. Serum inflammatory biomarkers including C-reactive protein (CRP), interleukin-6 (IL-6), procalcitonin (PCT) and ferritin levels were measured. Computed tomography images were analyzed and semi-automated measurements for EFV were obtained. The primary composite endpoint was admission to the intensive care unit (ICU) or death. ResultsThe primary composite endpoint occurred in 25.1% (n=26) of patients (mean age 64.8±14.8 years, 14 male). A total of 10 patients died. EFV, CRP, PCT, ferritin and IL-6 levels were significantly higher in ICU patients. Moreover, a positive correlation was determined between EFV and CRP (r: 0.494, p<0.001), PCT (r: 0.287, p=0.005), ferritin (r: 0.265, p=0.01) and IL-6 (r: 0.311, p=0.005). On receiver operating characteristic analysis, patients with EFV >102 cm3 were more likely to have severe complications. In multivariate logistic regression analysis, EFV independently predicted admission to the ICU at a significant level (OR: 1.02, 95% CI: 1.01-1.03, p=0.025). ConclusionEFV and serum CRP, IL-6, PCT and ferritin levels can effectively assess disease severity and predict the outcome in patients with COVID-19. EFV is an independent predictor of admission to the ICU in hospitalized COVID-19 patients. ER -