TY - JOUR T1 - Prognostic value of brain natriuretic peptide in ST-elevation myocardial infarction patients: A Portuguese registry JO - Revista Portuguesa de Cardiologia T2 - AU - Almeida,Inês AU - Chin,Joana AU - Santos,Hélder AU - Miranda,Hugo AU - Santos,Mariana AU - Sá,Catarina AU - Almeida,Samuel AU - Sousa,Catarina AU - Almeida,Lurdes SN - 08702551 M3 - 10.1016/j.repc.2020.12.016 DO - 10.1016/j.repc.2020.12.016 UR - https://www.revportcardiol.org/pt-prognostic-value-brain-natriuretic-peptide-articulo-S0870255121004431 AB - IntroductionBrain natriuretic peptide (BNP) is a highly sensitive and specific biomarker for the extent of myocardial infarction that is strongly related to short- and long-term prognosis in patients with acute coronary syndromes. ObjectiveTo assess the prognostic value of BNP levels in a Portuguese cohort of ST-elevation myocardial infarction (STEMI) patients. MethodsWe performed a retrospective analysis of patients admitted with STEMI included in the Portuguese Registry of Acute Coronary Syndromes (ProACS) between 2010 and 2019. Patients were divided into three groups according to BNP level (<100 pg/ml, 100-399 pg/ml and ≥400 pg/ml) and compared. Independent predictors of a composite of all-cause mortality and rehospitalization for cardiovascular causes were assessed by multivariate logistic regression. For sample homogenization, propensity score matching and pairwise matching with a tolerance level of 0.005 were performed. ResultsA total of 1650 patients were included, of whom 21.5% presented high BNP levels (≥400 pg/ml). These were older and had more comorbidities, lower admission systolic blood pressure and hemoglobin, higher heart rate, Killip class and creatinine, worse left ventricular systolic function and severe coronary anatomy. Higher BNP was associated with more in-hospital complications, in-hospital mortality and adverse outcomes at one year. ConclusionBNP levels during the index hospitalization were a powerful prognostic biomarker for all-cause mortality and major adverse cardiac events in patients admitted with STEMI to Portuguese hospitals. ER -