Original Research
Comparison of Positron Emission Tomography Measurement of Adenosine-Stimulated Absolute Myocardial Blood Flow Versus Relative Myocardial Tracer Content for Physiological Assessment of Coronary Artery Stenosis Severity and Location

https://doi.org/10.1016/j.jcmg.2009.04.004Get rights and content
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Objectives

This study tests the hypothesis that absolute measurement of adenosine (Ado)-stimulated myocardial blood flow (MBFado) is superior to measurement of relative tracer uptake for identification of hemodynamically significant coronary artery disease (CAD).

Background

Positron emission tomography measurement of absolute myocardial blood flow (MBF) (13N-ammonia) with Ado has the capability to more accurately assess hemodynamic severity of CAD than measurement of relative tracer content (TC) (nCi/ml) during Ado, which by definition depends on at least 1 normal zone to which others are compared.

Methods

A total of 27 patients (20 male, 58 ± 11 years, mean ± SD) with known or suspected CAD and 21 normal subjects (13 male, 38 ± 10 years) were studied. Parametric (K1) MBF images and TC sum images were analyzed. A stenosis ≥70% defined significant CAD. The receiver-operator characteristic curve (ROC) analysis area under the curve (AUC) compared MBF and TC results. Cut-point analysis for sensitivity, specificity, and accuracy showed the best MBF criteria for CAD as MBFado <1.85 ml/min/g and the best TC as <70% maximum. The myocardial blood flow reserve ratio (MBFR) (optimal <2.0×) also was studied.

Results

The ROC analysis of PET parameters showed that MBFado was superior to <70% maximum uptake for CAD detection (n = 144 vessels; AUC 0.900 vs. 0.690, respectively, p < 0.0001) and was marginally greater than MBFR (0.856; p = 0.10). For CAD cut-point analysis, MBFado accuracy exceeded TC (0.84 vs. 0.72, respectively, p = 0.005), as did sensitivity (0.81 vs. 0.48, respectively; p = 0.001). Specificity of MBFado for CAD classification (0.85) was comparable to TC (0.82; p = NS). Sensitivity, specificity, and predictive accuracy for MBFR were 0.62, 0.85, and 0.79, respectively. The difference in specificity was not significant versus MBFado. However, MBFado was more sensitive than MBFR (p = 0.01). The difference in predictive accuracy was borderline (p = 0.06) in favor of MBFado.

Conclusions

Measurement of Ado-stimulated absolute MBF is superior to relative measurement of myocardial tracer retention for identification of CAD and can be accomplished with a single MBFado measurement.

Key Words

PET
myocardial blood flow
coronary artery disease

Abbreviations and Acronyms

Ado
adenosine
AUC
area under the curve
CAD
coronary artery disease
LAD
left anterior descending coronary artery
LCX
left circumflex coronary artery
MBF
myocardial blood flow
MBFado
adenosine-stimulated myocardial blood flow
MBFR
myocardial blood flow reserve ratio
MPI
myocardial perfusion imaging
PET
positron emission tomography
RCA
right coronary artery
ROC
receiver-operator characteristic curve
TC
tracer content

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Supported in part by unrestricted grants from Astellas Pharma US to Dr. Gewirtz.