Original InvestigationEvaluation of Mavacamten in Symptomatic Patients With Nonobstructive Hypertrophic Cardiomyopathy
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This study was supported by MyoKardia, Inc. MyoKardia, Inc. was involved in the study design and interpretation of the data, analysis, writing of the report, and in the decision to submit the manuscript for publication. Dr. Ho has been a consultant and a member of the EXPLORER study steering committee for MyoKardia, Inc.; and has served on an advisory board for Ambry Genetics. Drs. Mealiffe, Edelberg, Bhattacharya, Sehnert, and Ma hold stock in MyoKardia, Inc. Dr. Hegde has performed Core Imaging Lab services for MyoKardia, Inc. Dr. Bach has received an institutional grant from MyoKardia, Inc. Dr. Jacoby has received grants from and consulting fees/honorarium for serving on an Advisory Board for MyoKardia, Inc.; and has been a member of the Steering Committee for EXPLORER. Dr. Lakdawala has received consulting fees/honorarium from MyoKardia, Inc. Dr. Marian has received travel expense reimbursements from MyoKardia, Inc. Dr. Owens has received consulting fees/honorarium from MyoKardia, Inc. Dr. Rader has received consulting fees/honorarium and other support from MyoKardia, Inc. Dr. Saberi has received honorarium and travel expense reimbursement for serving on an Advisory Board for MyoKardia, Inc. Dr. Sherrid has received consulting fees/honorarium and other support from Celltrion, Inc. Dr. Solomon has received grants from Alnylam, Amgen, AstraZeneca, Bellerophon, Bayer, Bristol-Myers Squibb, Celladon, Cytokinetics, Eidos, Gilead, GlaxoSmithKline, Ionis, Lone Star Heart, Mesoblast, MyoKardia, Inc., National Institutes of Health/National Heart, Lung, and Blood Institute, Novartis, Sanofi Pasteur, and Theracos; and has received consulting fees/honorarium from Akros, Alnylam, Amgen, Arena, AstraZeneca, Bayer, Bristol-Myers Squibb, Cardior, Corvia, Cytokinetics, Daiichi-Sankyo, Gilead, GlaxoSmithKline, Ironwood, Merck, MyoKardia, Inc., Novartis, Roche, Takeda, Theracos, Quantum Genetics, Cardurion, AoBiome, Janssen, Cardiac Dimensions, and Tenaya. Dr. Wang has received grants from, has been a primary investigator, and serves on the steering committee for the EXPLORER trial for MyoKardia, Inc.; and has served on an Advisory Board and received an educational grant for the HCM Care App. Dr. Wong has received support to attend an investigator’s meeting for MyoKardia, Inc. Dr. Heitner has received grants from MyoKardia, Inc. during the conduct of the study; and has received other support from MyoKardia, Inc. and Cytokinetics. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
The authors attest they are in compliance with human studies committees and animal welfare regulations of the authors’ institutions and Food and Drug Administration guidelines, including patient consent where appropriate. For more information, visit the JACC author instructions page.