CardiomyopathyQuantification of Myocardial Iron Deficiency in Nonischemic Heart Failure by Cardiac T2* Magnetic Resonance Imaging
Section snippets
Methods
Two hundred twenty-eight consecutive patients who had been admitted to our hospital from June 2010 to March 2013 with symptomatic congestive HF and echocardiographic left ventricular ejection fraction (LVEF) <50% were prospectively enrolled in this study. Congestive HF was diagnosed by the following clinical symptoms and signs according to the Framingham criteria: typical symptoms, neck vein distension, peripheral edema, lung rales, S3 gallop, and tachycardia together with representative chest
Results
T2* value had significant correlations with LV functional parameters (LV end-diastolic volume index, LV end-systolic volume index, and LVEF), which were observed in all patients. There were weak correlations between the T2* value and age and between T2* value and BNP. No correlation between T2* value and any other factor was observed (Table 2). No difference in T2* value between with and without LGE was observed in each patient group (Table 3). T2* value was significantly greater for patients
Discussion
The present study quantified myocardial iron content in patients with moderate to advanced HF and normal ventricular function using T2* CMR. T2* value was correlated with LV functional parameters and was significantly greater in patients with nonischemic HF than ischemic HF or patients with normal function. Furthermore, among patients with nonischemic HF, multivariate regression analysis showed a significant correlation between T2* value and LVEF. These results suggest that myocardial iron
Disclosures
Drs. Nagao and Kawanami received research grants from Bayer HealthCare Japan (Tokyo, Japan) and Philips Electronics Japan. Mr. Takemura is an employee of Philips Electronics Japan (Tokyo, Japan). The other authors have no conflicts of interest to disclose.
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2021, NefrologiaCitation Excerpt :However, there are some important differences worth noting. Myocardial iron content has been shown to be lower in HF, measured by magnetic resonance imaging (MRI)4 as well as in samples of left ventricle of the human heart.5 The role of iron in keeping the normal activity of key enzymes in the mitochondria has been invoked as a potential, although speculative explanation for the symptomatic benefit of iron administration in this setting.5,6
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2018, Journal of the American College of CardiologyCitation Excerpt :The potential of imaging to detect MID is currently emerging. In this regard, a study (n = 198) in symptomatic HF has shown that a lower iron myocardial content (measured by T2* CMR) predicted nonischemic HF (particularly when LVEF <35%; C-statistic: 0.78) and risk of future major adverse cardiac events (C-statistic: 0.66) (33). A small study in a similar population (nonischemic HF in 7 of 8 patients) used T2* CMR before and after 1,000 mg of ferric carboxymaltose (FCM).
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This work was supported by grant 25461831 from the Japan Society for the Promotion of Science (JSPS) KAKENHI (Tokyo, Japan).
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