TY - JOUR T1 - Acute coronay syndrome in a patient with severe hemophilia A: Dificult decisions JO - Revista Portuguesa de Cardiologia (English edition) T2 - AU - Aguiar-Ricardo,Inês AU - Agostinho,João AU - Pereira,Artur AU - Rodrigues,Fátima AU - Brito,Dulce AU - Pinto,Fausto J. AU - Catarino,Cristina AU - Mendes Pedro,Mónica SN - 21742049 M3 - 10.1016/j.repce.2021.10.002 DO - 10.1016/j.repce.2021.10.002 UR - https://www.revportcardiol.org/en-acute-coronay-syndrome-in-patient-articulo-S2174204921002841 AB - Hemophilia A is an inherited coagulation disease characterized by factor VIII (FVIII) deficiency and is associated with high hemorrhagic risk, especially in its severe forms. As the average life expectancy of patients with hemophilia has increased, so has the prevalence of acute coronary events. There is however limited experience in dealing with them. The strategy of acting on acute coronary events in patients with hemophilia, as demonstrated in the present case, is a real challenge, not only due to the need for antiplatelet therapy (which is essential in the prevention of stent thrombosis, but increases hemorrhagic risk), but also due to the lack of specific recommendations related to the most adequate and safe replacement therapy in these situations. The authors describe the case of a 48-year-old man with unstable angina and a previous diagnosis of severe hemophilia A who underwent percutaneous coronary intervention under FVIII therapy without hemorrhagic complications. ER -