TY - JOUR T1 - Mitral annulus is dilated with preserved function in acromegaly regardless of its activity: Insights from the three-dimensional speckle-tracking echocardiographic MAGYAR-Path Study JO - Revista Portuguesa de Cardiologia (English edition) T2 - AU - Nemes,Attila AU - Kormányos,Árpád AU - Domsik,Péter AU - Kalapos,Anita AU - Lengyel,Csaba AU - Ambrus,Nóra AU - Valkusz,Zsuzsanna SN - 21742049 M3 - 10.1016/j.repce.2020.07.014 DO - 10.1016/j.repce.2020.07.014 UR - https://www.revportcardiol.org/en-mitral-annulus-is-dilated-with-articulo-S2174204921001021 AB - Introduction and ObjectiveAcromegaly is a rare, chronic and slowly developing endocrine disorder caused by hypersecretion of human growth hormone and consequently of insulin-like growth factor-1 during adulthood. The present study was conducted to assess mitral annular (MA) size and function between acromegalic patients and age- and gender-matched healthy controls by three-dimensional speckle-tracking echocardiography (3D-STE). It also aimed to examine whether activity of the disease has any effect on MA parameters. MethodsThis study included 27 patients with acromegaly, three of whom were excluded due to inferior image quality. The mean age of the remaining 24 patients was 55.7±14.0 years and seven were male. Complete two-dimensional Doppler echocardiography and 3D-STE were performed in all cases. ResultsSignificantly increased end-diastolic and end-systolic MA diameter (2.81±0.36 cm vs. 2.44±0.34 cm and 2.00±0.32 cm vs. 1.65±0.37 cm, respectively), area (9.67±2.33 cm2 vs. 7.38±1.93 cm2 and 5.14±1.62 cm2 vs. 3.74±1.19 cm2, respectively) and perimeter (11.76±1.42 cm vs. 10.27±1.33 cm and 8.61±1.23 cm vs. 7.36±1.10 cm, respectively) were demonstrated in acromegalic patients compared with control subjects. MA functional parameters were not significantly altered compared to those of healthy individuals. ConclusionsMA dilation could be seen in acromegaly regardless of its activity. Acromegaly is not associated with MA functional impairment. ER -