TY - JOUR T1 - Is metabolic syndrome a prognostic marker in patients at high cardiovascular risk? A long-term cohort study JO - Revista Portuguesa de Cardiologia (English edition) T2 - AU - Timóteo,Ana Teresa AU - Mota Carmo,Miguel AU - Soares,Cristina AU - Cruz Ferreira,Rui SN - 21742049 M3 - 10.1016/j.repce.2018.06.011 DO - 10.1016/j.repce.2018.06.011 UR - https://www.revportcardiol.org/en-is-metabolic-syndrome-prognostic-marker-articulo-S2174204919301382 AB - IntroductionObese patients are at higher cardiovascular risk in primary prevention. In secondary prevention, an obesity paradox has been reported. We analyzed a cohort of individuals from a previous cross-sectional study on the impact of metabolic syndrome (MS) on coronary artery disease (CAD), aiming to assess the occurrence of cardiovascular events in a long follow-up. MethodsWe analyzed 296 individuals in a mean follow-up of 6.9±2.2 years. Subjects were divided into four groups according to the presence of MS or CAD (defined as ≥70% coronary stenosis). ResultsThe study population had a mean age of 65±9 years at the beginning of the study; 59.5% were male, 55.7% had MS and 41.6% had CAD. During follow-up 10.1% of the population suffered all-cause death, 3.7% cardiovascular death, 14.2% cardiovascular readmission and 22.0% the composite outcome (mortality, acute coronary syndrome, coronary revascularization, stroke/transient ischemic attack or heart failure admission). There were no significant differences in any type of mortality. Patients with CAD had more readmissions and composite outcomes (log-rank p<0.001 and p=0.001, respectively), but there was no difference according to the presence of MS. Only CAD was an independent predictor of cardiovascular admission (HR 3.21, 95% CI 1.66-6.21) and composite outcomes (HR 2.41, 95% CI 1.44-4.02). ConclusionsIn patients with high cardiovascular risk or established CAD, the presence of MS is not associated with cerebral or cardiac events in long-term follow-up. ER -