TY - JOUR T1 - Prognostic value of plasma neutrophil gelatinase-associated lipocalin in patients with heart failure JO - Revista Portuguesa de Cardiologia (English edition) T2 - AU - Villacorta,Humberto AU - Martins Santos,Rochele Alberto AU - Baco Marroig,Marcelle Alves AU - Guedes Pereira,Guilherme Pinella AU - Xavier,Analucia Rampazzo AU - Kanaan,Salim SN - 21742049 M3 - 10.1016/j.repce.2015.07.008 DO - 10.1016/j.repce.2015.07.008 UR - https://www.revportcardiol.org/en-prognostic-value-plasma-neutrophil-gelatinase-associated-articulo-S2174204915001622 AB - BackgroundNeutrophil gelatinase-associated lipocalin (NGAL) is an early marker of kidney injury. We sought to assess the prognostic value of this biomarker in patients with stable chronic heart failure (HF). MethodsWe studied 61 patients with chronic systolic HF who had been receiving optimal medical treatment for at least six months. Biomarkers were measured at baseline and included plasma NGAL, microalbuminuria, serum creatinine, and B-type natriuretic peptide (BNP). Estimated glomerular filtration rate (eGFR) was also calculated. Mean follow-up was 10.6±6.6 months. The primary endpoint was time to first cardiovascular event, defined as a combination of cardiovascular death, HF hospitalization or emergency department visit due to HF. Variables independently related to events were determined using a Cox proportional hazards model. ResultsFifteen (24.6%) patients reached the primary endpoint. Patients with events were more likely to have worse renal function at baseline and also higher NGAL levels (median 316 [interquartile range 122–705] vs. 107 [78–170]; p=0.006). NGAL correlated significantly with creatinine (r=0.50; p<0.0001), albuminuria (r=0.33; p=0.008), and eGFR (r=−0.47; p=0.0001) but not with BNP (r=0.003; p=0.97). The best NGAL cutoff as determined by ROC curve analysis was 179 ng/ml. Event-free survival was lower in patients with NGAL above this cutoff. Variables independently related to events were NGAL (HR 1.0035, 95% CI 1.0019–1.0052; p<0.0001) and male gender (HR 5.9, 95% CI 1.22–28.6; p=0.028). ConclusionNGAL correlated with other biomarkers of renal function but not with BNP and was independently associated with outcomes. ER -