TY - JOUR T1 - Left atrial dysfunction in light-chain cardiac amyloidosis and hypertrophic cardiomyopathy – A comparative three-dimensional speckle-tracking echocardiographic analysis from the MAGYAR-Path Study JO - Revista Portuguesa de Cardiologia (English edition) T2 - AU - Földeák,Dóra AU - Kormányos,Árpád AU - Domsik,Péter AU - Kalapos,Anita AU - Piros,Györgyike Á. AU - Ambrus,Nóra AU - Ajtay,Zénó AU - Sepp,Róbert AU - Borbényi,Zita AU - Forster,Tamás AU - Nemes,Attila SN - 21742049 M3 - 10.1016/j.repce.2017.06.011 DO - 10.1016/j.repce.2017.06.011 UR - https://www.revportcardiol.org/en-left-atrial-dysfunction-in-light-chain-articulo-S2174204917303811 AB - IntroductionWhile cardiac amyloidosis (CA) is a rare systemic disease characterized by extracellular deposition of protein-derived fibrils, hypertrophic cardiomyopathy (HCM) is histopathologically characterized by myocyte hypertrophy and disarray, interstitial fibrosis, and small intramural coronary arteriole dysplasia. The aim of the present study was to compare left atrial (LA) volumetric and functional characteristics between light-chain (AL) CA and HCM by three-dimensional (3D) speckle-tracking echocardiography (STE). MethodsThe AL-CA group initially consisted of 17 patients with AL-CA, but one patient was excluded due to inadequate image quality, and so the study population consisted of 16 patients (mean age: 64.0±9.6 years, five men). Their results were compared with data on 20 age-matched HCM patients (mean age: 59.8±5.2 years, 10 men) and on 16 age-matched healthy controls (mean age: 58.2±7.2 years, six men). Complete two-dimensional Doppler echocardiography and 3D-STE were performed in all cases. ResultsSignificantly increased LA volumes were observed in both AL-CA and HCM compared with the control group. Only active atrial emptying fraction was found to be significantly reduced in AL-CA patients compared to controls. Peak global and mean segmental circumferential, longitudinal and area strains showed significant reductions in AL-CA patients compared with controls, but only peak mean segmental longitudinal strain differed significantly between HCM patients and controls. While no differences were demonstrated in global and mean segmental strain at atrial contraction between HCM patients and controls, AL-CA patients showed reductions in certain strain parameters compared to controls and HCM patients. ConclusionsDifferent patterns of LA functional characteristics were demonstrated in AL-CA and HCM patients by 3D-STE. ER -